Detailed information of TA system TA294316

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 811738..812045
• Replicon: chromosome
• Accession: NZ_LT992476
• Organism: Staphylococcus aureus isolate 21_LA_436

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: DXE57_RS04160
• Protein ID: WP_011447039.1
• Coordinates: 811738..811914 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	811906..812045 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE57_RS04140	806973..810758	+	3786	WP_000582165.1	hypothetical protein	-
DXE57_RS04145	810748..810900	+	153	WP_001153681.1	hypothetical protein	-
DXE57_RS04150	810947..811234	+	288	WP_001040261.1	hypothetical protein	-
DXE57_RS04155	811292..811588	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
DXE57_RS04160	811738..811914	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	811906..812045	-	140	NuclAT_0	-	Antitoxin
-	811906..812045	-	140	NuclAT_0	-	Antitoxin
-	811906..812045	-	140	NuclAT_0	-	Antitoxin
-	811906..812045	-	140	NuclAT_0	-	Antitoxin
DXE57_RS04165	811967..812074	-	108	WP_001791821.1	hypothetical protein	-
DXE57_RS04170	812126..812380	+	255	WP_000611512.1	phage holin	-
DXE57_RS04175	812392..813147	+	756	WP_000861038.1	CHAP domain-containing protein	-
DXE57_RS04180	813338..813829	+	492	WP_000920037.1	staphylokinase	-
DXE57_RS04190	814479..814814	+	336	Protein_800	SH3 domain-containing protein	-
DXE57_RS04195	814909..815358	-	450	WP_114668899.1	chemotaxis-inhibiting protein CHIPS	-
DXE57_RS04200	816043..816393	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
DXE57_RS04205	816446..816706	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / chp / scn	774378..820903	46525

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T294316 WP_011447039.1 NZ_LT992476:811738-811914 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT294316 NZ_LT992476:c812045-811906 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin