Detailed information of TA system TA294302

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 364569..364876
• Replicon: chromosome
• Accession: NZ_LT992475
• Organism: Staphylococcus aureus isolate 20_LA_415

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: DXE41_RS02060
• Protein ID: WP_011447039.1
• Coordinates: 364569..364745 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	364737..364876 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE41_RS02040	359804..363589	+	3786	WP_031889405.1	phage minor structural protein	-
DXE41_RS02045	363579..363731	+	153	WP_001153681.1	hypothetical protein	-
DXE41_RS02050	363778..364065	+	288	WP_001040261.1	hypothetical protein	-
DXE41_RS02055	364123..364419	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
DXE41_RS02060	364569..364745	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	364737..364876	-	140	NuclAT_0	-	Antitoxin
-	364737..364876	-	140	NuclAT_0	-	Antitoxin
-	364737..364876	-	140	NuclAT_0	-	Antitoxin
-	364737..364876	-	140	NuclAT_0	-	Antitoxin
DXE41_RS02065	364798..364905	-	108	WP_001791821.1	hypothetical protein	-
DXE41_RS02070	364957..365211	+	255	WP_000611512.1	phage holin	-
DXE41_RS02075	365223..365978	+	756	WP_000861038.1	CHAP domain-containing protein	-
DXE41_RS02080	366169..366660	+	492	WP_000919350.1	staphylokinase	-
DXE41_RS02090	367310..367645	+	336	Protein_385	SH3 domain-containing protein	-
DXE41_RS02095	367740..368189	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
DXE41_RS02100	368874..369224	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
DXE41_RS02105	369277..369537	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	318250..369224	50974

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T294302 WP_011447039.1 NZ_LT992475:364569-364745 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT294302 NZ_LT992475:c364876-364737 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin