Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 364569..364907 Replicon chromosome
Accession NZ_LT992475
Organism Staphylococcus aureus isolate 20_LA_415

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag DXE41_RS02060 Protein ID WP_011447039.1
Coordinates 364569..364745 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 364733..364907 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE41_RS02040 359804..363589 + 3786 WP_031889405.1 phage minor structural protein -
DXE41_RS02045 363579..363731 + 153 WP_001153681.1 hypothetical protein -
DXE41_RS02050 363778..364065 + 288 WP_001040261.1 hypothetical protein -
DXE41_RS02055 364123..364419 + 297 WP_000539688.1 DUF2951 domain-containing protein -
DXE41_RS02060 364569..364745 + 177 WP_011447039.1 putative holin-like toxin Toxin
- 364733..364907 - 175 - - Antitoxin
DXE41_RS02070 364957..365211 + 255 WP_000611512.1 phage holin -
DXE41_RS02075 365223..365978 + 756 WP_000861038.1 CHAP domain-containing protein -
DXE41_RS02080 366169..366660 + 492 WP_000919350.1 staphylokinase -
DXE41_RS02090 367310..367645 + 336 Protein_385 SH3 domain-containing protein -
DXE41_RS02095 367740..368189 - 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
DXE41_RS02100 368874..369224 + 351 WP_000702263.1 complement inhibitor SCIN-A -
DXE41_RS02105 369277..369537 - 261 WP_001791826.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / hlb / sak / chp / scn 318250..369224 50974


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T294300 WP_011447039.1 NZ_LT992475:364569-364745 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 175 bp

>AT294300 NZ_LT992475:c364907-364733 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References