29429

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1332780..1333228 Replicon chromosome
Accession NC_021214
Organism Thermotoga maritima MSB8

Toxin (Protein)


Gene name hicA Uniprot ID Q9X138
Locus tag TMARI_RS06675 Protein ID WP_004079902.1
Coordinates 1332780..1333013 (-) Length 78 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID G4FE38
Locus tag TMARI_RS06680 Protein ID WP_004079900.1
Coordinates 1333010..1333228 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TMARI_RS06640 1328298..1329104 + 807 WP_004079915.1 ABC transporter permease -
TMARI_RS06650 1329322..1329756 + 435 WP_004079914.1 ABC transporter permease -
TMARI_RS09880 1329760..1330530 + 771 Protein_1287 ABC transporter permease -
TMARI_RS06665 1330593..1332335 + 1743 WP_004079909.1 ABC transporter ATP-binding protein/permease -
TMARI_RS09790 1332406..1332555 - 150 WP_081434644.1 type II toxin-antitoxin system HicA family toxin -
TMARI_RS06670 1332545..1332757 - 213 WP_004079908.1 hypothetical protein -
TMARI_RS06675 1332780..1333013 - 234 WP_004079902.1 type II toxin-antitoxin system HicA family toxin Toxin
TMARI_RS06680 1333010..1333228 - 219 WP_004079900.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
TMARI_RS09885 1333325..1334933 - 1609 Protein_1293 helix-turn-helix domain-containing protein -
TMARI_RS06690 1335129..1335293 + 165 WP_004083364.1 hypothetical protein -
TMARI_RS06695 1335370..1335465 + 96 WP_010865309.1 Cys-rich RiPP peptide -
TMARI_RS06700 1335567..1336958 + 1392 WP_004083362.1 radical SAM protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1325066..1336958 11892


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-65)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-56)


Sequences

Toxin        


Download         Length: 78 a.a.        Molecular weight: 8983.60 Da        Isoelectric Point: 10.4691

>T29429 WP_004079902.1 NC_021214:c1333013-1332780 [Thermotoga maritima MSB8]
MSYLPIVDPKTMEKVLLKLGFQRVRQKGSHVFYRHSNGKYTTIPFHAKETCPSHLIRKIIREAGISVEEFKKVLENL

Download         Length: 234 bp

>T29429 NC_021214:c1333013-1332780 [Thermotoga maritima MSB8]
TTGAGTTATCTTCCAATAGTTGATCCAAAAACTATGGAAAAGGTTTTACTGAAACTTGGATTTCAACGTGTTCGCCAAAA
AGGAAGTCATGTGTTCTACAGGCACAGCAATGGAAAGTATACGACCATCCCATTTCATGCAAAAGAGACTTGCCCAAGTC
ACTTAATAAGAAAAATCATCCGTGAAGCGGGTATATCAGTGGAGGAATTCAAGAAAGTACTTGAGAATCTGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8186.38 Da        Isoelectric Point: 4.0891

>AT29429 WP_004079900.1 NC_021214:c1333228-1333010 [Thermotoga maritima MSB8]
VRKIFTAIIEYDPEKKQYVGMVPDVPGVHTVGSSLEEVRRNLKEVLELVLEEAGDEINLQEFVALEMIEVET

Download         Length: 219 bp

>AT29429 NC_021214:c1333228-1333010 [Thermotoga maritima MSB8]
GTGCGTAAAATTTTCACAGCTATCATTGAATACGATCCTGAAAAAAAGCAATATGTTGGAATGGTTCCAGATGTTCCAGG
TGTACATACTGTAGGTAGTTCCTTAGAAGAAGTGAGAAGGAATTTAAAAGAGGTGCTTGAACTCGTATTGGAGGAAGCAG
GAGATGAAATAAATCTCCAGGAATTCGTGGCTCTTGAGATGATAGAGGTGGAAACTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9X138

Antitoxin

Source ID Structure
AlphaFold DB G4FE38

References