Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1332780..1333228 Replicon chromosome
Accession NC_021214
Organism Thermotoga maritima MSB8

Toxin (Protein)


Gene name hicA Uniprot ID Q9X138
Locus tag TMARI_RS06675 Protein ID WP_004079902.1
Coordinates 1332780..1333013 (-) Length 78 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID G4FE38
Locus tag TMARI_RS06680 Protein ID WP_004079900.1
Coordinates 1333010..1333228 (-) Length 73 a.a.

Genomic Context

TMARI_RS06640TMARI_RS06650TMARI_RS09880TMARI_RS06665TMARI_RS06690TMARI_RS06695TMARI_RS06700TMARI_RS09790TMARI_RS06670TMARI_RS06675TMARI_RS06680TMARI_RS09885
Location: 1328298..1329104 (807 bp)
Type: Others
Protein ID: WP_004079915.1
Location: 1329322..1329756 (435 bp)
Type: Others
Protein ID: WP_004079914.1
Location: 1329760..1330530 (771 bp)
Type: Others
Protein ID: Protein_1287
Location: 1330593..1332335 (1743 bp)
Type: Others
Protein ID: WP_004079909.1
Location: 1335129..1335293 (165 bp)
Type: Others
Protein ID: WP_004083364.1
Location: 1335370..1335465 (96 bp)
Type: Others
Protein ID: WP_010865309.1
Location: 1335567..1336958 (1392 bp)
Type: Others
Protein ID: WP_004083362.1
Location: 1332406..1332555 (150 bp)
Type: Others
Protein ID: WP_081434644.1
Location: 1332545..1332757 (213 bp)
Type: Others
Protein ID: WP_004079908.1
Location: 1332780..1333013 (234 bp)
Type: Toxin
Protein ID: WP_004079902.1
Location: 1333010..1333228 (219 bp)
Type: Antitoxin
Protein ID: WP_004079900.1
Location: 1333325..1334933 (1609 bp)
Type: Others
Protein ID: Protein_1293
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
TMARI_RS066401328298..1329104+807WP_004079915.1ABC transporter permease-
TMARI_RS066501329322..1329756+435WP_004079914.1ABC transporter permease-
TMARI_RS098801329760..1330530+771Protein_1287ABC transporter permease-
TMARI_RS066651330593..1332335+1743WP_004079909.1ABC transporter ATP-binding protein/permease-
TMARI_RS097901332406..1332555-150WP_081434644.1type II toxin-antitoxin system HicA family toxin-
TMARI_RS066701332545..1332757-213WP_004079908.1hypothetical protein-
TMARI_RS066751332780..1333013-234WP_004079902.1type II toxin-antitoxin system HicA family toxinToxin
TMARI_RS066801333010..1333228-219WP_004079900.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
TMARI_RS098851333325..1334933-1609Protein_1293helix-turn-helix domain-containing protein-
TMARI_RS066901335129..1335293+165WP_004083364.1hypothetical protein-
TMARI_RS066951335370..1335465+96WP_010865309.1Cys-rich RiPP peptide-
TMARI_RS067001335567..1336958+1392WP_004083362.1radical SAM protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideGenomic island--1325066..133695811892


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-65)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-56)


Sequences

Toxin        


Download         Length: 78 a.a.        Molecular weight: 8983.60 Da        Isoelectric Point: 10.4691

>T29429 WP_004079902.1 NC_021214:c1333013-1332780 [Thermotoga maritima MSB8]
MSYLPIVDPKTMEKVLLKLGFQRVRQKGSHVFYRHSNGKYTTIPFHAKETCPSHLIRKIIREAGISVEEFKKVLENL

Download         Length: 234 bp

>T29429 NC_021214:c1333013-1332780 [Thermotoga maritima MSB8]
TTGAGTTATCTTCCAATAGTTGATCCAAAAACTATGGAAAAGGTTTTACTGAAACTTGGATTTCAACGTGTTCGCCAAAA
AGGAAGTCATGTGTTCTACAGGCACAGCAATGGAAAGTATACGACCATCCCATTTCATGCAAAAGAGACTTGCCCAAGTC
ACTTAATAAGAAAAATCATCCGTGAAGCGGGTATATCAGTGGAGGAATTCAAGAAAGTACTTGAGAATCTGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8186.38 Da        Isoelectric Point: 4.0891

>AT29429 WP_004079900.1 NC_021214:c1333228-1333010 [Thermotoga maritima MSB8]
VRKIFTAIIEYDPEKKQYVGMVPDVPGVHTVGSSLEEVRRNLKEVLELVLEEAGDEINLQEFVALEMIEVET

Download         Length: 219 bp

>AT29429 NC_021214:c1333228-1333010 [Thermotoga maritima MSB8]
GTGCGTAAAATTTTCACAGCTATCATTGAATACGATCCTGAAAAAAAGCAATATGTTGGAATGGTTCCAGATGTTCCAGG
TGTACATACTGTAGGTAGTTCCTTAGAAGAAGTGAGAAGGAATTTAAAAGAGGTGCTTGAACTCGTATTGGAGGAAGCAG
GAGATGAAATAAATCTCCAGGAATTCGTGGCTCTTGAGATGATAGAGGTGGAAACTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9X138

Antitoxin

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Source
ID
Structure
AlphaFold DBG4FE38

References