Detailed information of TA system TA294287

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2650954..2651261
• Replicon: chromosome
• Accession: NZ_LT992474
• Organism: Staphylococcus aureus isolate 19_LA_388

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: DXE66_RS13580
• Protein ID: WP_072357969.1
• Coordinates: 2651085..2651261 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2650954..2651093 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE66_RS13525	2646298..2646558	+	261	WP_001791826.1	hypothetical protein	-
DXE66_RS13530	2646611..2646961	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
DXE66_RS13535	2647644..2648093	+	450	WP_000727643.1	chemotaxis-inhibiting protein CHIPS	-
DXE66_RS13540	2648186..2648520	-	335	Protein_2513	SH3 domain-containing protein	-
DXE66_RS13560	2649170..2649661	-	492	WP_000920041.1	staphylokinase	-
DXE66_RS13565	2649852..2650607	-	756	WP_000861038.1	CHAP domain-containing protein	-
DXE66_RS13570	2650619..2650873	-	255	WP_000611512.1	phage holin	-
DXE66_RS13575	2650925..2651032	+	108	WP_031762631.1	hypothetical protein	-
-	2650954..2651093	+	140	NuclAT_0	-	Antitoxin
-	2650954..2651093	+	140	NuclAT_0	-	Antitoxin
-	2650954..2651093	+	140	NuclAT_0	-	Antitoxin
-	2650954..2651093	+	140	NuclAT_0	-	Antitoxin
DXE66_RS13580	2651085..2651261	-	177	WP_072357969.1	putative holin-like toxin	Toxin
DXE66_RS13585	2651404..2651778	-	375	WP_000340977.1	hypothetical protein	-
DXE66_RS13590	2651834..2652121	-	288	WP_001262620.1	hypothetical protein	-
DXE66_RS13595	2652167..2652319	-	153	WP_001000058.1	hypothetical protein	-
DXE66_RS13600	2652312..2656094	-	3783	WP_114639804.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2646611..2698085	51474

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T294287 WP_072357969.1 NZ_LT992474:c2651261-2651085 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT294287 NZ_LT992474:2650954-2651093 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin