Detailed information of TA system TA294282

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 961265..961844
• Replicon: chromosome
• Accession: NZ_LT992474
• Organism: Staphylococcus aureus isolate 19_LA_388

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: DXE66_RS04770
• Protein ID: WP_001025401.1
• Coordinates: 961265..961510 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	961479..961844 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE66_RS04725	957283..957897	+	615	WP_000191461.1	hypothetical protein	-
DXE66_RS04730	957894..958040	-	147	WP_001013104.1	hypothetical protein	-
DXE66_RS04735	958270..958854	-	585	WP_000825948.1	hypothetical protein	-
DXE66_RS04740	958872..959333	-	462	WP_000525004.1	hypothetical protein	-
DXE66_RS04745	959346..959660	-	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
DXE66_RS04750	959812..960048	+	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
DXE66_RS04755	960062..960838	+	777	WP_001148544.1	Rha family transcriptional regulator	-
DXE66_RS04760	960867..961010	+	144	WP_000939498.1	hypothetical protein	-
DXE66_RS04765	961000..961209	-	210	WP_000642492.1	hypothetical protein	-
DXE66_RS04770	961265..961510	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
DXE66_RS04775	961479..961844	-	366	WP_001128433.1	hypothetical protein	Antitoxin
DXE66_RS04780	961899..962114	+	216	WP_001036302.1	hypothetical protein	-
DXE66_RS04785	962139..962402	+	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
DXE66_RS04790	962415..962576	+	162	WP_001285963.1	DUF1270 family protein	-
DXE66_RS04795	962655..962978	+	324	WP_000174994.1	hypothetical protein	-
DXE66_RS04800	962993..963355	+	363	WP_000985976.1	hypothetical protein	-
DXE66_RS04805	963352..964518	+	1167	WP_000762545.1	DUF2800 domain-containing protein	-
DXE66_RS04810	964544..965101	+	558	WP_031915349.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	955968..1001033	45065

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T294282 WP_001025401.1 NZ_LT992474:961265-961510 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT294282 NZ_LT992474:c961844-961479 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin