Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1840728..1841247 Replicon chromosome
Accession NC_021213
Organism Streptococcus suis TL13

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0Z8K9K9
Locus tag TL13_RS09050 Protein ID WP_015647467.1
Coordinates 1840728..1840985 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag TL13_RS09055 Protein ID WP_002939010.1
Coordinates 1840987..1841247 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TL13_RS09035 1837361..1839091 - 1731 WP_015647464.1 hypothetical protein -
TL13_RS09040 1839292..1840200 - 909 WP_079266809.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
TL13_RS09045 1840184..1840714 - 531 WP_015647466.1 DUF1697 domain-containing protein -
TL13_RS09050 1840728..1840985 - 258 WP_015647467.1 Txe/YoeB family addiction module toxin Toxin
TL13_RS09055 1840987..1841247 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
TL13_RS09060 1841323..1841778 - 456 WP_015647468.1 8-oxo-dGTP diphosphatase -
TL13_RS09065 1841782..1842150 - 369 WP_015647469.1 hypothetical protein -
TL13_RS09070 1842143..1842712 - 570 WP_015647470.1 ribonuclease M5 -
TL13_RS09075 1842696..1843478 - 783 WP_015647471.1 TatD family hydrolase -
TL13_RS09080 1843585..1843722 - 138 WP_002939016.1 50S ribosomal protein L34 -
TL13_RS09085 1843890..1844885 - 996 WP_015647472.1 protein jag -
TL13_RS09090 1844905..1845717 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
TL13_RS09095 1845701..1846060 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10378.92 Da        Isoelectric Point: 8.0279

>T29428 WP_015647467.1 NC_021213:c1840985-1840728 [Streptococcus suis TL13]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMMEADRLCILSL
KDHYR

Download         Length: 258 bp

>T29428 NC_021213:c1840985-1840728 [Streptococcus suis TL13]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAAGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCAAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCAAGAAGGATTGATGCGGAGAATCGGTTGATTTATATGATGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT29428 WP_002939010.1 NC_021213:c1841247-1840987 [Streptococcus suis TL13]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT29428 NC_021213:c1841247-1840987 [Streptococcus suis TL13]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAAGACTATATGAAAAAGGTCAATGACGAGTTTGAGCCCTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8K9K9

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References