Detailed information of TA system TA294278

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2695297..2695604
• Replicon: chromosome
• Accession: NZ_LT992473
• Organism: Staphylococcus aureus isolate 14_5418

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: DXE48_RS13685
• Protein ID: WP_011447039.1
• Coordinates: 2695297..2695473 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2695465..2695604 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE48_RS13665	2690532..2694317	+	3786	WP_000582165.1	hypothetical protein	-
DXE48_RS13670	2694307..2694459	+	153	WP_001153681.1	hypothetical protein	-
DXE48_RS13675	2694506..2694793	+	288	WP_001040261.1	hypothetical protein	-
DXE48_RS13680	2694851..2695147	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
DXE48_RS13685	2695297..2695473	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	2695465..2695604	-	140	NuclAT_0	-	Antitoxin
-	2695465..2695604	-	140	NuclAT_0	-	Antitoxin
-	2695465..2695604	-	140	NuclAT_0	-	Antitoxin
-	2695465..2695604	-	140	NuclAT_0	-	Antitoxin
DXE48_RS13690	2695526..2695633	-	108	WP_001791821.1	hypothetical protein	-
DXE48_RS13695	2695685..2695939	+	255	WP_000611512.1	phage holin	-
DXE48_RS13700	2695951..2696706	+	756	WP_000861038.1	CHAP domain-containing protein	-
DXE48_RS13705	2696897..2697388	+	492	WP_000919350.1	staphylokinase	-
DXE48_RS13715	2698038..2698373	+	336	Protein_2569	SH3 domain-containing protein	-
DXE48_RS13720	2698468..2698917	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
DXE48_RS13725	2699602..2699952	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
DXE48_RS13730	2700005..2700265	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	2648330..2699952	51622

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T294278 WP_011447039.1 NZ_LT992473:2695297-2695473 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT294278 NZ_LT992473:c2695604-2695465 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin