Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 2695297..2695635 Replicon chromosome
Accession NZ_LT992473
Organism Staphylococcus aureus isolate 14_5418

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag DXE48_RS13685 Protein ID WP_011447039.1
Coordinates 2695297..2695473 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2695461..2695635 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE48_RS13665 2690532..2694317 + 3786 WP_000582165.1 hypothetical protein -
DXE48_RS13670 2694307..2694459 + 153 WP_001153681.1 hypothetical protein -
DXE48_RS13675 2694506..2694793 + 288 WP_001040261.1 hypothetical protein -
DXE48_RS13680 2694851..2695147 + 297 WP_000539688.1 DUF2951 domain-containing protein -
DXE48_RS13685 2695297..2695473 + 177 WP_011447039.1 putative holin-like toxin Toxin
- 2695461..2695635 - 175 - - Antitoxin
DXE48_RS13695 2695685..2695939 + 255 WP_000611512.1 phage holin -
DXE48_RS13700 2695951..2696706 + 756 WP_000861038.1 CHAP domain-containing protein -
DXE48_RS13705 2696897..2697388 + 492 WP_000919350.1 staphylokinase -
DXE48_RS13715 2698038..2698373 + 336 Protein_2569 SH3 domain-containing protein -
DXE48_RS13720 2698468..2698917 - 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
DXE48_RS13725 2699602..2699952 + 351 WP_000702263.1 complement inhibitor SCIN-A -
DXE48_RS13730 2700005..2700265 - 261 WP_001791826.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / hlb / sak / chp / scn 2648330..2699952 51622


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T294276 WP_011447039.1 NZ_LT992473:2695297-2695473 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 175 bp

>AT294276 NZ_LT992473:c2695635-2695461 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References