Detailed information of TA system TA294268

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1542798..1543377
• Replicon: chromosome
• Accession: NZ_LT992473
• Organism: Staphylococcus aureus isolate 14_5418

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: DXE48_RS07830
• Protein ID: WP_001025401.1
• Coordinates: 1543132..1543377 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1542798..1543163 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE48_RS07790	1539541..1540098	-	558	WP_031915349.1	DUF2815 family protein	-
DXE48_RS07795	1540124..1541290	-	1167	WP_000762545.1	DUF2800 domain-containing protein	-
DXE48_RS07800	1541287..1541649	-	363	WP_000985976.1	hypothetical protein	-
DXE48_RS07805	1541664..1541987	-	324	WP_000174994.1	hypothetical protein	-
DXE48_RS07810	1542066..1542227	-	162	WP_001285948.1	DUF1270 domain-containing protein	-
DXE48_RS07815	1542240..1542503	-	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
DXE48_RS07820	1542528..1542743	-	216	WP_001036302.1	hypothetical protein	-
DXE48_RS07825	1542798..1543163	+	366	WP_001128433.1	hypothetical protein	Antitoxin
DXE48_RS07830	1543132..1543377	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
DXE48_RS07835	1543433..1543642	+	210	WP_000642492.1	hypothetical protein	-
DXE48_RS07840	1543632..1543775	-	144	WP_000939498.1	hypothetical protein	-
DXE48_RS07845	1543804..1544580	-	777	WP_031886646.1	Rha family transcriptional regulator	-
DXE48_RS07850	1544619..1544828	-	210	WP_001114715.1	helix-turn-helix transcriptional regulator	-
DXE48_RS07855	1544991..1545317	+	327	WP_000455972.1	helix-turn-helix domain-containing protein	-
DXE48_RS07860	1545339..1545797	+	459	WP_000521395.1	hypothetical protein	-
DXE48_RS07865	1545815..1546399	+	585	WP_000825948.1	hypothetical protein	-
DXE48_RS07870	1546629..1546775	+	147	WP_001013104.1	hypothetical protein	-
DXE48_RS07875	1546772..1547386	-	615	WP_000191461.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	geh	1503609..1559271	55662

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T294268 WP_001025401.1 NZ_LT992473:c1543377-1543132 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT294268 NZ_LT992473:1542798-1543163 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin