Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 1680343..1680681 Replicon chromosome
Accession NZ_LT992472
Organism Staphylococcus aureus isolate 10_5235

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag DXE26_RS08740 Protein ID WP_011447039.1
Coordinates 1680343..1680519 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 1680507..1680681 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE26_RS08720 1675578..1679363 + 3786 WP_001644870.1 phage minor structural protein -
DXE26_RS08725 1679353..1679505 + 153 WP_001153681.1 hypothetical protein -
DXE26_RS08730 1679552..1679839 + 288 WP_001040261.1 hypothetical protein -
DXE26_RS08735 1679897..1680193 + 297 WP_000539688.1 DUF2951 domain-containing protein -
DXE26_RS08740 1680343..1680519 + 177 WP_011447039.1 putative holin-like toxin Toxin
- 1680507..1680681 - 175 - - Antitoxin
DXE26_RS08750 1680731..1680985 + 255 WP_000611512.1 phage holin -
DXE26_RS08755 1680997..1681752 + 756 WP_000861038.1 CHAP domain-containing protein -
DXE26_RS08760 1681943..1682434 + 492 WP_000919350.1 staphylokinase -
DXE26_RS08770 1683084..1683419 + 336 Protein_1604 SH3 domain-containing protein -
DXE26_RS08775 1683514..1683963 - 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
DXE26_RS08780 1684648..1684998 + 351 WP_000702263.1 complement inhibitor SCIN-A -
DXE26_RS08785 1685051..1685311 - 261 WP_001791826.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sak / chp / scn 1638891..1690464 51573


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T294259 WP_011447039.1 NZ_LT992472:1680343-1680519 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 175 bp

>AT294259 NZ_LT992472:c1680681-1680507 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References