Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2330809..2331088 Replicon chromosome
Accession NZ_LT992471
Organism Staphylococcus aureus isolate 17_LA_343

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag DXE46_RS12145 Protein ID WP_001802298.1
Coordinates 2330984..2331088 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2330809..2330988 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE46_RS12125 2327010..2327675 - 666 WP_001024099.1 SDR family oxidoreductase -
DXE46_RS12130 2327827..2328147 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
DXE46_RS12135 2328149..2329129 + 981 WP_000019735.1 CDF family zinc efflux transporter CzrB -
DXE46_RS12140 2329395..2330486 + 1092 WP_000495673.1 hypothetical protein -
- 2330809..2330988 + 180 - - Antitoxin
DXE46_RS12145 2330984..2331088 - 105 WP_001802298.1 hypothetical protein Toxin
DXE46_RS12160 2331768..2331926 + 159 WP_001792784.1 hypothetical protein -
DXE46_RS12165 2332362..2332454 + 93 WP_000220902.1 hypothetical protein -
DXE46_RS12170 2332584..2333441 - 858 WP_000370942.1 Cof-type HAD-IIB family hydrolase -
DXE46_RS12175 2333509..2334291 - 783 WP_000908191.1 ABC transporter ATP-binding protein -
DXE46_RS12180 2334581..2335189 - 609 WP_000101714.1 TIR domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T294248 WP_001802298.1 NZ_LT992471:c2331088-2330984 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

Antitoxin


Download         Length: 180 bp

>AT294248 NZ_LT992471:2330809-2330988 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References