Detailed information of TA system TA294248

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2330809..2331088
• Replicon: chromosome
• Accession: NZ_LT992471
• Organism: Staphylococcus aureus isolate 17_LA_343

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: DXE46_RS12145
• Protein ID: WP_001802298.1
• Coordinates: 2330984..2331088 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2330809..2330988 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE46_RS12125	2327010..2327675	-	666	WP_001024099.1	SDR family oxidoreductase	-
DXE46_RS12130	2327827..2328147	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
DXE46_RS12135	2328149..2329129	+	981	WP_000019735.1	CDF family zinc efflux transporter CzrB	-
DXE46_RS12140	2329395..2330486	+	1092	WP_000495673.1	hypothetical protein	-
-	2330809..2330988	+	180	-	-	Antitoxin
DXE46_RS12145	2330984..2331088	-	105	WP_001802298.1	hypothetical protein	Toxin
DXE46_RS12160	2331768..2331926	+	159	WP_001792784.1	hypothetical protein	-
DXE46_RS12165	2332362..2332454	+	93	WP_000220902.1	hypothetical protein	-
DXE46_RS12170	2332584..2333441	-	858	WP_000370942.1	Cof-type HAD-IIB family hydrolase	-
DXE46_RS12175	2333509..2334291	-	783	WP_000908191.1	ABC transporter ATP-binding protein	-
DXE46_RS12180	2334581..2335189	-	609	WP_000101714.1	TIR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T294248 WP_001802298.1 NZ_LT992471:c2331088-2330984 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

Antitoxin

Nucleotide

• Length: 180 bp

>AT294248 NZ_LT992471:2330809-2330988 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin