Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 2158339..2158638 Replicon chromosome
Accession NZ_LT992471
Organism Staphylococcus aureus isolate 17_LA_343

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag DXE46_RS11155 Protein ID WP_011447039.1
Coordinates 2158462..2158638 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2158339..2158394 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE46_RS11110 2154166..2154413 + 248 Protein_2058 sphingomyelin phosphodiesterase -
DXE46_RS11115 2154735..2154914 + 180 WP_000669789.1 hypothetical protein -
DXE46_RS11125 2155225..2155485 + 261 WP_001791826.1 hypothetical protein -
DXE46_RS11130 2155538..2155888 - 351 WP_000702263.1 complement inhibitor SCIN-A -
DXE46_RS11135 2156547..2157038 - 492 WP_000919350.1 staphylokinase -
DXE46_RS11140 2157229..2157984 - 756 WP_064131634.1 CHAP domain-containing protein -
DXE46_RS11145 2157996..2158250 - 255 WP_000611512.1 phage holin -
DXE46_RS11150 2158302..2158409 + 108 WP_001791821.1 hypothetical protein -
- 2158331..2158470 + 140 NuclAT_0 - -
- 2158331..2158470 + 140 NuclAT_0 - -
- 2158331..2158470 + 140 NuclAT_0 - -
- 2158331..2158470 + 140 NuclAT_0 - -
- 2158339..2158394 + 56 - - Antitoxin
DXE46_RS11155 2158462..2158638 - 177 WP_011447039.1 putative holin-like toxin Toxin
DXE46_RS11160 2158788..2159084 - 297 WP_000539688.1 DUF2951 domain-containing protein -
DXE46_RS11165 2159142..2159429 - 288 WP_001040261.1 hypothetical protein -
DXE46_RS11170 2159476..2159628 - 153 WP_001153681.1 hypothetical protein -
DXE46_RS11175 2159618..2163402 - 3785 Protein_2070 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / sak / hlb / groEL 2155538..2205448 49910


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T294244 WP_011447039.1 NZ_LT992471:c2158638-2158462 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 56 bp

>AT294244 NZ_LT992471:2158339-2158394 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References