Detailed information of TA system TA294238

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 397686..398265
• Replicon: chromosome
• Accession: NZ_LT992471
• Organism: Staphylococcus aureus isolate 17_LA_343

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: DXE46_RS01875
• Protein ID: WP_001025401.1
• Coordinates: 397686..397931 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	397900..398265 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE46_RS01810	392784..393398	+	615	WP_000191459.1	hypothetical protein	-
DXE46_RS01815	393395..393541	-	147	WP_078067907.1	hypothetical protein	-
DXE46_RS01820	393629..394024	-	396	WP_000449655.1	hypothetical protein	-
DXE46_RS01825	394053..394487	-	435	WP_031910435.1	hypothetical protein	-
DXE46_RS01830	394505..394966	-	462	WP_031910436.1	toxin	-
DXE46_RS01835	394979..395302	-	324	WP_001260487.1	helix-turn-helix domain-containing protein	-
DXE46_RS01840	395466..395714	+	249	WP_000272859.1	helix-turn-helix domain-containing protein	-
DXE46_RS01845	395727..396170	+	444	WP_000435362.1	hypothetical protein	-
DXE46_RS15245	396185..396334	+	150	WP_000771849.1	hypothetical protein	-
DXE46_RS01850	396375..396587	-	213	WP_000362644.1	hypothetical protein	-
DXE46_RS01855	396657..396854	+	198	WP_001148860.1	hypothetical protein	-
DXE46_RS01860	396841..397221	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
DXE46_RS01865	397288..397431	+	144	WP_000939498.1	hypothetical protein	-
DXE46_RS01870	397421..397630	-	210	WP_000642492.1	hypothetical protein	-
DXE46_RS01875	397686..397931	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
DXE46_RS01880	397900..398265	-	366	WP_016170627.1	hypothetical protein	Antitoxin
DXE46_RS01885	398320..398535	+	216	WP_001097552.1	hypothetical protein	-
DXE46_RS01890	398560..398823	+	264	WP_016187436.1	helix-turn-helix domain-containing protein	-
DXE46_RS01895	398836..398997	+	162	WP_001285948.1	DUF1270 domain-containing protein	-
DXE46_RS01900	399076..399399	+	324	WP_000174994.1	hypothetical protein	-
DXE46_RS01905	399414..399776	+	363	WP_000985976.1	hypothetical protein	-
DXE46_RS01910	399773..400939	+	1167	WP_031794951.1	DUF2800 domain-containing protein	-
DXE46_RS01915	400966..401523	+	558	WP_000645049.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	391453..438212	46759

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T294238 WP_001025401.1 NZ_LT992471:397686-397931 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT294238 NZ_LT992471:c398265-397900 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTACGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin