Detailed information of TA system TA294235

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2599017..2599324
• Replicon: chromosome
• Accession: NZ_LT992470
• Organism: Staphylococcus aureus isolate 13_LA_301

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: DXE64_RS13340
• Protein ID: WP_011447039.1
• Coordinates: 2599017..2599193 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2599185..2599324 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE64_RS13320	2594252..2598037	+	3786	WP_000582165.1	hypothetical protein	-
DXE64_RS13325	2598027..2598179	+	153	WP_001153681.1	hypothetical protein	-
DXE64_RS13330	2598226..2598513	+	288	WP_001040261.1	hypothetical protein	-
DXE64_RS13335	2598571..2598867	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
DXE64_RS13340	2599017..2599193	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	2599185..2599324	-	140	NuclAT_0	-	Antitoxin
-	2599185..2599324	-	140	NuclAT_0	-	Antitoxin
-	2599185..2599324	-	140	NuclAT_0	-	Antitoxin
-	2599185..2599324	-	140	NuclAT_0	-	Antitoxin
DXE64_RS13345	2599246..2599353	-	108	WP_001791821.1	hypothetical protein	-
DXE64_RS13350	2599405..2599659	+	255	WP_000611512.1	phage holin	-
DXE64_RS13355	2599671..2600426	+	756	WP_000861038.1	CHAP domain-containing protein	-
DXE64_RS13360	2600617..2601108	+	492	WP_000919350.1	staphylokinase	-
DXE64_RS13370	2601758..2602093	+	336	Protein_2482	SH3 domain-containing protein	-
DXE64_RS13375	2602188..2602637	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
DXE64_RS13380	2603322..2603672	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
DXE64_RS13385	2603725..2603985	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	2552050..2603672	51622

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T294235 WP_011447039.1 NZ_LT992470:2599017-2599193 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT294235 NZ_LT992470:c2599324-2599185 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin