294233

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 2599017..2599355 Replicon chromosome
Accession NZ_LT992470
Organism Staphylococcus aureus isolate 13_LA_301

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag DXE64_RS13340 Protein ID WP_011447039.1
Coordinates 2599017..2599193 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2599181..2599355 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE64_RS13320 2594252..2598037 + 3786 WP_000582165.1 hypothetical protein -
DXE64_RS13325 2598027..2598179 + 153 WP_001153681.1 hypothetical protein -
DXE64_RS13330 2598226..2598513 + 288 WP_001040261.1 hypothetical protein -
DXE64_RS13335 2598571..2598867 + 297 WP_000539688.1 DUF2951 domain-containing protein -
DXE64_RS13340 2599017..2599193 + 177 WP_011447039.1 putative holin-like toxin Toxin
- 2599181..2599355 - 175 - - Antitoxin
DXE64_RS13350 2599405..2599659 + 255 WP_000611512.1 phage holin -
DXE64_RS13355 2599671..2600426 + 756 WP_000861038.1 CHAP domain-containing protein -
DXE64_RS13360 2600617..2601108 + 492 WP_000919350.1 staphylokinase -
DXE64_RS13370 2601758..2602093 + 336 Protein_2482 SH3 domain-containing protein -
DXE64_RS13375 2602188..2602637 - 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
DXE64_RS13380 2603322..2603672 + 351 WP_000702263.1 complement inhibitor SCIN-A -
DXE64_RS13385 2603725..2603985 - 261 WP_001791826.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / hlb / sak / chp / scn 2552050..2603672 51622


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T294233 WP_011447039.1 NZ_LT992470:2599017-2599193 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 175 bp

>AT294233 NZ_LT992470:c2599355-2599181 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References