Detailed information of TA system TA294225

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1446503..1447082
• Replicon: chromosome
• Accession: NZ_LT992470
• Organism: Staphylococcus aureus isolate 13_LA_301

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: DXE64_RS07490
• Protein ID: WP_001025401.1
• Coordinates: 1446837..1447082 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1446503..1446868 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE64_RS07450	1443246..1443803	-	558	WP_031915349.1	DUF2815 family protein	-
DXE64_RS07455	1443829..1444995	-	1167	WP_000762545.1	DUF2800 domain-containing protein	-
DXE64_RS07460	1444992..1445354	-	363	WP_000985976.1	hypothetical protein	-
DXE64_RS07465	1445369..1445692	-	324	WP_000174994.1	hypothetical protein	-
DXE64_RS07470	1445771..1445932	-	162	WP_001285948.1	DUF1270 domain-containing protein	-
DXE64_RS07475	1445945..1446208	-	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
DXE64_RS07480	1446233..1446448	-	216	WP_001036302.1	hypothetical protein	-
DXE64_RS07485	1446503..1446868	+	366	WP_001128433.1	hypothetical protein	Antitoxin
DXE64_RS07490	1446837..1447082	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
DXE64_RS07495	1447138..1447347	+	210	WP_000642492.1	hypothetical protein	-
DXE64_RS07500	1447337..1447480	-	144	WP_000939498.1	hypothetical protein	-
DXE64_RS07505	1447509..1448285	-	777	WP_031886646.1	Rha family transcriptional regulator	-
DXE64_RS07510	1448324..1448533	-	210	WP_001114715.1	helix-turn-helix transcriptional regulator	-
DXE64_RS07515	1448696..1449022	+	327	WP_000455972.1	helix-turn-helix domain-containing protein	-
DXE64_RS07520	1449044..1449502	+	459	WP_000521395.1	hypothetical protein	-
DXE64_RS07525	1449520..1450104	+	585	WP_000825948.1	hypothetical protein	-
DXE64_RS07530	1450334..1450480	+	147	WP_001013104.1	hypothetical protein	-
DXE64_RS07535	1450477..1451091	-	615	WP_000191461.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1407314..1452406	45092

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T294225 WP_001025401.1 NZ_LT992470:c1447082-1446837 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT294225 NZ_LT992470:1446503-1446868 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin