Detailed information of TA system TA294215

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 714845..715424
• Replicon: chromosome
• Accession: NZ_LT992469
• Organism: Staphylococcus aureus isolate 15_LA_305

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: DXE36_RS04010
• Protein ID: WP_001025401.1
• Coordinates: 714845..715090 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	715059..715424 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE36_RS03960	710158..710772	+	615	WP_000191466.1	hypothetical protein	-
DXE36_RS03965	710769..710915	-	147	WP_001794606.1	hypothetical protein	-
DXE36_RS03970	711145..711729	-	585	WP_000825948.1	hypothetical protein	-
DXE36_RS03975	711747..712208	-	462	WP_000525004.1	hypothetical protein	-
DXE36_RS03980	712221..712535	-	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
DXE36_RS03985	712687..712923	+	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
DXE36_RS03990	712937..713713	+	777	WP_001148544.1	Rha family transcriptional regulator	-
DXE36_RS14990	713742..713891	+	150	WP_000771849.1	hypothetical protein	-
DXE36_RS03995	713932..714144	-	213	WP_000362644.1	hypothetical protein	-
DXE36_RS04000	714214..714411	+	198	WP_001148860.1	hypothetical protein	-
DXE36_RS04005	714398..714778	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
DXE36_RS04010	714845..715090	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
DXE36_RS04015	715059..715424	-	366	WP_001128433.1	hypothetical protein	Antitoxin
DXE36_RS04020	715479..715694	+	216	WP_001097552.1	hypothetical protein	-
DXE36_RS04025	715721..715984	+	264	WP_001596347.1	helix-turn-helix domain-containing protein	-
DXE36_RS04030	715997..716158	+	162	WP_001285948.1	DUF1270 domain-containing protein	-
DXE36_RS04035	716237..716560	+	324	WP_000174994.1	hypothetical protein	-
DXE36_RS04040	716575..716937	+	363	WP_031863778.1	hypothetical protein	-
DXE36_RS04045	716934..718100	+	1167	WP_079219804.1	DUF2800 domain-containing protein	-
DXE36_RS04050	718126..718683	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	705850..756024	50174

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T294215 WP_001025401.1 NZ_LT992469:714845-715090 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT294215 NZ_LT992469:c715424-715059 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin