Detailed information of TA system TA294212

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 247635..247942
• Replicon: chromosome
• Accession: NZ_LT992469
• Organism: Staphylococcus aureus isolate 15_LA_305

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: DXE36_RS01415
• Protein ID: WP_011447039.1
• Coordinates: 247635..247811 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	247803..247942 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE36_RS01395	242870..246655	+	3786	WP_001644870.1	phage minor structural protein	-
DXE36_RS01400	246645..246797	+	153	WP_001153681.1	hypothetical protein	-
DXE36_RS01405	246844..247131	+	288	WP_001040261.1	hypothetical protein	-
DXE36_RS01410	247189..247485	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
DXE36_RS01415	247635..247811	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	247803..247942	-	140	NuclAT_0	-	Antitoxin
-	247803..247942	-	140	NuclAT_0	-	Antitoxin
-	247803..247942	-	140	NuclAT_0	-	Antitoxin
-	247803..247942	-	140	NuclAT_0	-	Antitoxin
DXE36_RS01420	247864..247971	-	108	WP_001791821.1	hypothetical protein	-
DXE36_RS01425	248023..248277	+	255	WP_000611512.1	phage holin	-
DXE36_RS01430	248289..249044	+	756	WP_000861038.1	CHAP domain-containing protein	-
DXE36_RS01435	249235..249726	+	492	WP_114665717.1	staphylokinase	-
DXE36_RS01440	250385..250735	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
DXE36_RS01445	250788..251048	-	261	WP_001791826.1	hypothetical protein	-
DXE36_RS01455	251359..251538	-	180	WP_000669789.1	hypothetical protein	-
DXE36_RS01460	251860..252107	-	248	Protein_265	sphingomyelin phosphodiesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / scn	200859..250735	49876

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T294212 WP_011447039.1 NZ_LT992469:247635-247811 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT294212 NZ_LT992469:c247942-247803 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin