294210

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 247635..247973 Replicon chromosome
Accession NZ_LT992469
Organism Staphylococcus aureus isolate 15_LA_305

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag DXE36_RS01415 Protein ID WP_011447039.1
Coordinates 247635..247811 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 247799..247973 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE36_RS01395 242870..246655 + 3786 WP_001644870.1 phage minor structural protein -
DXE36_RS01400 246645..246797 + 153 WP_001153681.1 hypothetical protein -
DXE36_RS01405 246844..247131 + 288 WP_001040261.1 hypothetical protein -
DXE36_RS01410 247189..247485 + 297 WP_000539688.1 DUF2951 domain-containing protein -
DXE36_RS01415 247635..247811 + 177 WP_011447039.1 putative holin-like toxin Toxin
- 247799..247973 - 175 - - Antitoxin
DXE36_RS01425 248023..248277 + 255 WP_000611512.1 phage holin -
DXE36_RS01430 248289..249044 + 756 WP_000861038.1 CHAP domain-containing protein -
DXE36_RS01435 249235..249726 + 492 WP_114665717.1 staphylokinase -
DXE36_RS01440 250385..250735 + 351 WP_000702263.1 complement inhibitor SCIN-A -
DXE36_RS01445 250788..251048 - 261 WP_001791826.1 hypothetical protein -
DXE36_RS01455 251359..251538 - 180 WP_000669789.1 hypothetical protein -
DXE36_RS01460 251860..252107 - 248 Protein_265 sphingomyelin phosphodiesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / hlb / sak / scn 200859..250735 49876


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T294210 WP_011447039.1 NZ_LT992469:247635-247811 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 175 bp

>AT294210 NZ_LT992469:c247973-247799 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References