Detailed information of TA system TA294204

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 14461..14768
• Replicon: chromosome
• Accession: NZ_LT992469
• Organism: Staphylococcus aureus isolate 15_LA_305

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: DXE36_RS00080
• Protein ID: WP_011447039.1
• Coordinates: 14461..14637 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	14629..14768 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE36_RS00060	9696..13481	+	3786	WP_075111493.1	hypothetical protein	-
DXE36_RS00065	13471..13623	+	153	WP_001153681.1	hypothetical protein	-
DXE36_RS00070	13670..13957	+	288	WP_001040254.1	hypothetical protein	-
DXE36_RS00075	14015..14311	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
DXE36_RS00080	14461..14637	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	14629..14768	-	140	NuclAT_1	-	Antitoxin
-	14629..14768	-	140	NuclAT_1	-	Antitoxin
-	14629..14768	-	140	NuclAT_1	-	Antitoxin
-	14629..14768	-	140	NuclAT_1	-	Antitoxin
DXE36_RS00085	14690..14797	-	108	WP_031790389.1	hypothetical protein	-
DXE36_RS00090	14849..15103	+	255	WP_000611512.1	phage holin	-
DXE36_RS00095	15115..15870	+	756	WP_000861038.1	CHAP domain-containing protein	-
DXE36_RS00100	16061..16553	+	493	Protein_20	staphylokinase	-
DXE36_RS00105	17158..17496	+	339	Protein_21	SH3 domain-containing protein	-
DXE36_RS00110	18008..18358	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
DXE36_RS00115	18411..18671	-	261	WP_001791826.1	hypothetical protein	-
DXE36_RS00125	18980..19159	-	180	WP_000669789.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / sak / scn	676..18358	17682

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T294204 WP_011447039.1 NZ_LT992469:14461-14637 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT294204 NZ_LT992469:c14768-14629 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin