Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 535952..536251 Replicon chromosome
Accession NZ_LT992468
Organism Staphylococcus aureus isolate 12_LA_293

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag DXE47_RS03150 Protein ID WP_011447039.1
Coordinates 536075..536251 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 535952..536007 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE47_RS03105 531283..531543 + 261 WP_001791826.1 hypothetical protein -
DXE47_RS03110 531596..531946 - 351 WP_000702263.1 complement inhibitor SCIN-A -
DXE47_RS03115 532631..533080 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
DXE47_RS03120 533175..533510 - 336 Protein_564 SH3 domain-containing protein -
DXE47_RS03130 534160..534651 - 492 WP_000919350.1 staphylokinase -
DXE47_RS03135 534842..535597 - 756 WP_000861038.1 CHAP domain-containing protein -
DXE47_RS03140 535609..535863 - 255 WP_000611512.1 phage holin -
DXE47_RS03145 535915..536022 + 108 WP_001791821.1 hypothetical protein -
- 535944..536083 + 140 NuclAT_0 - -
- 535944..536083 + 140 NuclAT_0 - -
- 535944..536083 + 140 NuclAT_0 - -
- 535944..536083 + 140 NuclAT_0 - -
- 535952..536007 + 56 - - Antitoxin
DXE47_RS03150 536075..536251 - 177 WP_011447039.1 putative holin-like toxin Toxin
DXE47_RS03155 536401..536697 - 297 WP_000539688.1 DUF2951 domain-containing protein -
DXE47_RS03160 536755..537042 - 288 WP_001040261.1 hypothetical protein -
DXE47_RS03165 537089..537241 - 153 WP_001153681.1 hypothetical protein -
DXE47_RS03170 537231..541016 - 3786 WP_114621458.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / chp / sak / hlb / groEL 531596..584303 52707


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T294194 WP_011447039.1 NZ_LT992468:c536251-536075 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 56 bp

>AT294194 NZ_LT992468:535952-536007 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References