Detailed information of TA system TA294189

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2458077..2458326
• Replicon: chromosome
• Accession: NZ_LT992467
• Organism: Staphylococcus aureus isolate 16_LA_309

Toxin (Protein)

• Gene name: SprG2
• Uniprot ID: -
• Locus tag: DXE59_RS12800
• Protein ID: WP_000623369.1
• Coordinates: 2458077..2458184 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2458179..2458326 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE59_RS12775	2454751..2455320	-	570	WP_000287260.1	competence protein ComK	-
DXE59_RS12780	2455530..2455748	+	219	WP_000876826.1	IDEAL domain-containing protein	-
DXE59_RS12785	2455829..2456815	-	987	WP_000668814.1	lipoate--protein ligase	-
DXE59_RS12790	2457014..2457190	+	177	WP_000214898.1	YkvS family protein	-
DXE59_RS12795	2457205..2457807	+	603	WP_001033867.1	CPBP family intramembrane metalloprotease	-
DXE59_RS12800	2458077..2458184	+	108	WP_000623369.1	putative holin-like toxin	Toxin
-	2458179..2458326	-	148	-	-	Antitoxin
DXE59_RS12805	2458819..2459103	+	285	WP_000790905.1	lactococcin 972 family bacteriocin	-
DXE59_RS12810	2459147..2461111	+	1965	WP_000870811.1	bacteriocin-associated integral membrane family protein	-
DXE59_RS12815	2461114..2461434	+	321	WP_000668623.1	YxeA family protein	-
DXE59_RS12820	2461431..2462072	+	642	WP_000571192.1	ABC transporter ATP-binding protein	-
DXE59_RS12825	2462160..2462450	-	291	WP_001796515.1	hypothetical protein	-
DXE59_RS12830	2462540..2462728	+	189	WP_157958947.1	poly(glycerol-phosphate) alpha-glucosyltransferase	-
DXE59_RS12835	2462817..2463173	-	357	WP_000766009.1	DoxX family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3801.69 Da
• Isoelectric Point: 10.8004

>T294189 WP_000623369.1 NZ_LT992467:2458077-2458184 [Staphylococcus aureus]
VISIANALHLMLSFGMFIVTFIGVVVAIINLNNKK

Nucleotide

• Length: 108 bp

Antitoxin

Nucleotide

• Length: 148 bp

>AT294189 NZ_LT992467:c2458326-2458179 [Staphylococcus aureus]
CAATTAAATAAAAGATATGTTACTATAAAAATGTAAAAAGACGACATGCAGTAACATGTCGCCTAATGAGCCCGTTAAAA
AGACGGTGACTAAATGAGATTTGCTTTAACCATCATTCGTTGTCAAAGTTTTGAAATGATGGTTATTT

Structures

Antitoxin