Detailed information of TA system TA294179

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 591991..592298
• Replicon: chromosome
• Accession: NZ_LT992467
• Organism: Staphylococcus aureus isolate 16_LA_309

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: DXE59_RS03095
• Protein ID: WP_072357969.1
• Coordinates: 592122..592298 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	591991..592130 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE59_RS03040	587333..587593	+	261	WP_001791826.1	hypothetical protein	-
DXE59_RS03045	587646..587996	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
DXE59_RS03050	588679..589128	+	450	WP_000727643.1	chemotaxis-inhibiting protein CHIPS	-
DXE59_RS03055	589221..589555	-	335	Protein_546	SH3 domain-containing protein	-
DXE59_RS03075	590206..590697	-	492	WP_000920041.1	staphylokinase	-
DXE59_RS03080	590889..591644	-	756	WP_000861038.1	CHAP domain-containing protein	-
DXE59_RS03085	591656..591910	-	255	WP_000611512.1	phage holin	-
DXE59_RS03090	591962..592069	+	108	WP_031762631.1	hypothetical protein	-
-	591991..592130	+	140	NuclAT_0	-	Antitoxin
-	591991..592130	+	140	NuclAT_0	-	Antitoxin
-	591991..592130	+	140	NuclAT_0	-	Antitoxin
-	591991..592130	+	140	NuclAT_0	-	Antitoxin
DXE59_RS03095	592122..592298	-	177	WP_072357969.1	putative holin-like toxin	Toxin
DXE59_RS03100	592450..592746	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
DXE59_RS03105	592804..593091	-	288	WP_001040261.1	hypothetical protein	-
DXE59_RS03110	593138..593290	-	153	WP_001153681.1	hypothetical protein	-
DXE59_RS03115	593280..597065	-	3786	WP_114636066.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	587646..640141	52495

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T294179 WP_072357969.1 NZ_LT992467:c592298-592122 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT294179 NZ_LT992467:591991-592130 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin