Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 1054663..1055001 Replicon chromosome
Accession NZ_LT992466
Organism Staphylococcus aureus isolate 4_LA_208

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag DXE30_RS05340 Protein ID WP_011447039.1
Coordinates 1054663..1054839 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 1054827..1055001 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE30_RS05320 1049898..1053683 + 3786 WP_098827734.1 hypothetical protein -
DXE30_RS05325 1053673..1053825 + 153 WP_001153681.1 hypothetical protein -
DXE30_RS05330 1053872..1054159 + 288 WP_001040261.1 hypothetical protein -
DXE30_RS05335 1054217..1054513 + 297 WP_000539688.1 DUF2951 domain-containing protein -
DXE30_RS05340 1054663..1054839 + 177 WP_011447039.1 putative holin-like toxin Toxin
- 1054827..1055001 - 175 - - Antitoxin
DXE30_RS05350 1055051..1055305 + 255 WP_000611512.1 phage holin -
DXE30_RS05355 1055317..1056072 + 756 WP_000861038.1 CHAP domain-containing protein -
DXE30_RS05360 1056263..1056754 + 492 WP_000919350.1 staphylokinase -
DXE30_RS05370 1057359..1057697 + 339 Protein_1006 SH3 domain-containing protein -
DXE30_RS05375 1058208..1058558 + 351 WP_000702262.1 complement inhibitor SCIN-A -
DXE30_RS05380 1058611..1058871 - 261 WP_001791826.1 hypothetical protein -
DXE30_RS05390 1059182..1059361 - 180 WP_000669789.1 hypothetical protein -
DXE30_RS05395 1059683..1059930 - 248 Protein_1010 sphingomyelin phosphodiesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / hlb / sak / scn 1007102..1058558 51456


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T294170 WP_011447039.1 NZ_LT992466:1054663-1054839 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 175 bp

>AT294170 NZ_LT992466:c1055001-1054827 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References