Detailed information of TA system TA294162

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2517430..2517737
• Replicon: chromosome
• Accession: NZ_LT992465
• Organism: Staphylococcus aureus isolate 6_LA_232

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: DXE62_RS12835
• Protein ID: WP_011447039.1
• Coordinates: 2517430..2517606 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2517598..2517737 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE62_RS12815	2512665..2516450	+	3786	WP_000582165.1	hypothetical protein	-
DXE62_RS12820	2516440..2516592	+	153	WP_001153681.1	hypothetical protein	-
DXE62_RS12825	2516639..2516926	+	288	WP_001040261.1	hypothetical protein	-
DXE62_RS12830	2516984..2517280	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
DXE62_RS12835	2517430..2517606	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	2517598..2517737	-	140	NuclAT_0	-	Antitoxin
-	2517598..2517737	-	140	NuclAT_0	-	Antitoxin
-	2517598..2517737	-	140	NuclAT_0	-	Antitoxin
-	2517598..2517737	-	140	NuclAT_0	-	Antitoxin
DXE62_RS12840	2517659..2517766	-	108	WP_001791821.1	hypothetical protein	-
DXE62_RS12845	2517818..2518072	+	255	WP_000611512.1	phage holin	-
DXE62_RS12850	2518084..2518839	+	756	WP_000861038.1	CHAP domain-containing protein	-
DXE62_RS12855	2519030..2519521	+	492	WP_000919350.1	staphylokinase	-
DXE62_RS12865	2520171..2520506	+	336	Protein_2417	SH3 domain-containing protein	-
DXE62_RS12870	2520601..2521050	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
DXE62_RS12875	2521734..2522084	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
DXE62_RS12880	2522137..2522397	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	2469666..2522084	52418

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T294162 WP_011447039.1 NZ_LT992465:2517430-2517606 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT294162 NZ_LT992465:c2517737-2517598 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin