Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 2517430..2517768 Replicon chromosome
Accession NZ_LT992465
Organism Staphylococcus aureus isolate 6_LA_232

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag DXE62_RS12835 Protein ID WP_011447039.1
Coordinates 2517430..2517606 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2517594..2517768 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE62_RS12815 2512665..2516450 + 3786 WP_000582165.1 hypothetical protein -
DXE62_RS12820 2516440..2516592 + 153 WP_001153681.1 hypothetical protein -
DXE62_RS12825 2516639..2516926 + 288 WP_001040261.1 hypothetical protein -
DXE62_RS12830 2516984..2517280 + 297 WP_000539688.1 DUF2951 domain-containing protein -
DXE62_RS12835 2517430..2517606 + 177 WP_011447039.1 putative holin-like toxin Toxin
- 2517594..2517768 - 175 - - Antitoxin
DXE62_RS12845 2517818..2518072 + 255 WP_000611512.1 phage holin -
DXE62_RS12850 2518084..2518839 + 756 WP_000861038.1 CHAP domain-containing protein -
DXE62_RS12855 2519030..2519521 + 492 WP_000919350.1 staphylokinase -
DXE62_RS12865 2520171..2520506 + 336 Protein_2417 SH3 domain-containing protein -
DXE62_RS12870 2520601..2521050 - 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
DXE62_RS12875 2521734..2522084 + 351 WP_000702263.1 complement inhibitor SCIN-A -
DXE62_RS12880 2522137..2522397 - 261 WP_001791826.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / hlb / sak / chp / scn 2469666..2522084 52418


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T294160 WP_011447039.1 NZ_LT992465:2517430-2517606 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 175 bp

>AT294160 NZ_LT992465:c2517768-2517594 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References