Detailed information of TA system TA294148

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 59985..60564
• Replicon: chromosome
• Accession: NZ_LT992465
• Organism: Staphylococcus aureus isolate 6_LA_232

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: DXE62_RS00360
• Protein ID: WP_001025401.1
• Coordinates: 59985..60230 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	60199..60564 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE62_RS00310	55845..56459	+	615	WP_000191461.1	hypothetical protein	-
DXE62_RS00315	56456..56602	-	147	WP_001013104.1	hypothetical protein	-
DXE62_RS00320	56832..57416	-	585	WP_000825948.1	hypothetical protein	-
DXE62_RS00325	57434..57895	-	462	WP_000525004.1	hypothetical protein	-
DXE62_RS00330	57908..58231	-	324	WP_114637613.1	helix-turn-helix domain-containing protein	-
DXE62_RS00335	58395..58643	+	249	WP_000272859.1	helix-turn-helix domain-containing protein	-
DXE62_RS00340	58656..59099	+	444	WP_000435362.1	hypothetical protein	-
DXE62_RS14715	59114..59263	+	150	WP_000771849.1	hypothetical protein	-
DXE62_RS00345	59304..59516	-	213	WP_000362644.1	hypothetical protein	-
DXE62_RS00350	59587..59730	+	144	WP_000939498.1	hypothetical protein	-
DXE62_RS00355	59720..59929	-	210	WP_000642492.1	hypothetical protein	-
DXE62_RS00360	59985..60230	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
DXE62_RS00365	60199..60564	-	366	WP_001128433.1	hypothetical protein	Antitoxin
DXE62_RS00370	60619..60835	+	217	Protein_73	hypothetical protein	-
DXE62_RS00375	60862..61125	+	264	WP_001124195.1	helix-turn-helix domain-containing protein	-
DXE62_RS00380	61137..61298	+	162	WP_001285949.1	DUF1270 domain-containing protein	-
DXE62_RS00385	61377..61700	+	324	WP_000174994.1	hypothetical protein	-
DXE62_RS00390	61715..62077	+	363	WP_031775157.1	hypothetical protein	-
DXE62_RS00395	62074..63240	+	1167	WP_031795549.1	DUF2800 domain-containing protein	-
DXE62_RS00400	63266..63823	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	53712..112484	58772

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T294148 WP_001025401.1 NZ_LT992465:59985-60230 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT294148 NZ_LT992465:c60564-60199 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin