Detailed information of TA system TA294144

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2312424..2313003
• Replicon: chromosome
• Accession: NZ_LT992464
• Organism: Staphylococcus aureus isolate 3_LA_115

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: DXE56_RS12295
• Protein ID: WP_001025401.1
• Coordinates: 2312758..2313003 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2312424..2312789 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE56_RS12255	2309167..2309724	-	558	WP_031915349.1	DUF2815 family protein	-
DXE56_RS12260	2309750..2310916	-	1167	WP_000762545.1	DUF2800 domain-containing protein	-
DXE56_RS12265	2310913..2311275	-	363	WP_000985976.1	hypothetical protein	-
DXE56_RS12270	2311290..2311613	-	324	WP_000174994.1	hypothetical protein	-
DXE56_RS12275	2311692..2311853	-	162	WP_001285963.1	DUF1270 family protein	-
DXE56_RS12280	2311866..2312129	-	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
DXE56_RS12285	2312154..2312369	-	216	WP_001036302.1	hypothetical protein	-
DXE56_RS12290	2312424..2312789	+	366	WP_001128433.1	hypothetical protein	Antitoxin
DXE56_RS12295	2312758..2313003	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
DXE56_RS12300	2313059..2313268	+	210	WP_000642492.1	hypothetical protein	-
DXE56_RS12305	2313258..2313401	-	144	WP_000939498.1	hypothetical protein	-
DXE56_RS12310	2313430..2314206	-	777	WP_001148544.1	Rha family transcriptional regulator	-
DXE56_RS12315	2314220..2314456	-	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
DXE56_RS12320	2314608..2314922	+	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
DXE56_RS12325	2314935..2315396	+	462	WP_000525004.1	hypothetical protein	-
DXE56_RS12330	2315414..2315998	+	585	WP_000825948.1	hypothetical protein	-
DXE56_RS12335	2316228..2316374	+	147	WP_001013104.1	hypothetical protein	-
DXE56_RS12340	2316371..2316985	-	615	WP_000191461.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	geh	2273235..2329804	56569

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T294144 WP_001025401.1 NZ_LT992464:c2313003-2312758 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT294144 NZ_LT992464:2312424-2312789 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin