Detailed information of TA system TA029414

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 3153442..3153950
• Replicon: chromosome
• Accession: NC_021177
• Organism: Streptomyces fulvissimus DSM 40593

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: N0CS17
• Locus tag: SFUL_RS13720
• Protein ID: WP_015609077.1
• Coordinates: 3153690..3153950 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: N0CVS4
• Locus tag: SFUL_RS13715
• Protein ID: WP_015609076.1
• Coordinates: 3153442..3153693 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SFUL_RS13705	3149790..3151436	-	1647	WP_015609074.1	PQQ-binding-like beta-propeller repeat protein	-
SFUL_RS13710	3151482..3153302	-	1821	WP_015609075.1	ABC-F family ATP-binding cassette domain-containing protein	-
SFUL_RS13715	3153442..3153693	+	252	WP_015609076.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
SFUL_RS13720	3153690..3153950	+	261	WP_015609077.1	Txe/YoeB family addiction module toxin	Toxin
SFUL_RS13725	3153938..3155329	-	1392	WP_043974458.1	acyltransferase	-
SFUL_RS13730	3155648..3156388	+	741	WP_015609079.1	hypothetical protein	-
SFUL_RS13735	3156431..3157024	-	594	WP_015609080.1	XRE family transcriptional regulator	-
SFUL_RS13740	3157128..3157772	+	645	WP_015609081.1	class I SAM-dependent methyltransferase	-
SFUL_RS13745	3157827..3158771	-	945	WP_015609082.1	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10452.79 Da
• Isoelectric Point: 9.4245

>T29414 WP_015609077.1 NC_021177:3153690-3153950 [Streptomyces fulvissimus DSM 40593]
VKFVWDQSSWDDYVWWQNQDRKILKRINTLLQDIARNGNEGMGKPEPLKHGFQGYWSRRITDEHRLIYKVVDDEVRVAAC
RYHYGR

Nucleotide

• Length: 261 bp

>T29414 NC_021177:3153690-3153950 [Streptomyces fulvissimus DSM 40593]
GTGAAGTTCGTGTGGGATCAGTCGTCGTGGGACGACTACGTCTGGTGGCAGAACCAGGATCGCAAGATCCTCAAGAGGAT
CAACACACTGCTCCAGGACATCGCCCGGAACGGAAACGAGGGGATGGGCAAACCGGAACCGCTGAAGCACGGATTCCAGG
GGTACTGGTCCCGCCGCATCACCGATGAGCACCGGCTCATCTACAAGGTGGTCGACGACGAGGTCCGCGTCGCCGCCTGC
CGCTACCACTACGGTCGCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9299.37 Da
• Isoelectric Point: 4.4118

>AT29414 WP_015609076.1 NC_021177:3153442-3153693 [Streptomyces fulvissimus DSM 40593]
MRTMTYTESRAKYAETLSAVVDDREEVVVTRAGHEPVVIVALDEYESLKETAYQLRSPENARRLLASIDRLENGGGTVQE
LAE

Nucleotide

• Length: 252 bp

>AT29414 NC_021177:3153442-3153693 [Streptomyces fulvissimus DSM 40593]
ATGCGGACGATGACCTACACGGAGTCCCGGGCGAAGTACGCGGAGACCCTGAGTGCCGTCGTGGACGACCGCGAGGAGGT
CGTGGTCACGCGCGCCGGCCACGAGCCCGTGGTGATAGTGGCGCTCGATGAGTACGAGTCCCTCAAGGAGACGGCGTACC
AGCTCAGGAGCCCGGAGAACGCCCGTCGGCTGCTGGCTTCGATCGACCGCTTGGAGAACGGCGGCGGCACGGTACAGGAG
CTCGCGGAGTGA

Structures

Toxin

• AlphaFold DB: N0CS17

Antitoxin

• AlphaFold DB: N0CVS4