Detailed information of TA system TA294129

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2823907..2824214
• Replicon: chromosome
• Accession: NZ_LT992463
• Organism: Staphylococcus aureus isolate 2_LA_86

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: DXE29_RS14535
• Protein ID: WP_011447039.1
• Coordinates: 2823907..2824083 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2824075..2824214 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE29_RS14515	2819142..2822927	+	3786	WP_000582165.1	hypothetical protein	-
DXE29_RS14520	2822917..2823069	+	153	WP_001153681.1	hypothetical protein	-
DXE29_RS14525	2823116..2823403	+	288	WP_001040261.1	hypothetical protein	-
DXE29_RS14530	2823461..2823757	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
DXE29_RS14535	2823907..2824083	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	2824075..2824214	-	140	NuclAT_0	-	Antitoxin
-	2824075..2824214	-	140	NuclAT_0	-	Antitoxin
-	2824075..2824214	-	140	NuclAT_0	-	Antitoxin
-	2824075..2824214	-	140	NuclAT_0	-	Antitoxin
DXE29_RS14540	2824136..2824243	-	108	WP_001791821.1	hypothetical protein	-
DXE29_RS14545	2824295..2824549	+	255	WP_000611512.1	phage holin	-
DXE29_RS14550	2824561..2825316	+	756	WP_000861038.1	CHAP domain-containing protein	-
DXE29_RS14555	2825507..2825998	+	492	WP_000919350.1	staphylokinase	-
DXE29_RS14565	2826648..2826983	+	336	Protein_2696	SH3 domain-containing protein	-
DXE29_RS14570	2827078..2827527	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
DXE29_RS14575	2828212..2828562	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
DXE29_RS14580	2828615..2828875	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / chp / scn	2787718..2831145	43427

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T294129 WP_011447039.1 NZ_LT992463:2823907-2824083 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT294129 NZ_LT992463:c2824214-2824075 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin