294127

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 2823907..2824245 Replicon chromosome
Accession NZ_LT992463
Organism Staphylococcus aureus isolate 2_LA_86

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag DXE29_RS14535 Protein ID WP_011447039.1
Coordinates 2823907..2824083 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2824071..2824245 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE29_RS14515 2819142..2822927 + 3786 WP_000582165.1 hypothetical protein -
DXE29_RS14520 2822917..2823069 + 153 WP_001153681.1 hypothetical protein -
DXE29_RS14525 2823116..2823403 + 288 WP_001040261.1 hypothetical protein -
DXE29_RS14530 2823461..2823757 + 297 WP_000539688.1 DUF2951 domain-containing protein -
DXE29_RS14535 2823907..2824083 + 177 WP_011447039.1 putative holin-like toxin Toxin
- 2824071..2824245 - 175 - - Antitoxin
DXE29_RS14545 2824295..2824549 + 255 WP_000611512.1 phage holin -
DXE29_RS14550 2824561..2825316 + 756 WP_000861038.1 CHAP domain-containing protein -
DXE29_RS14555 2825507..2825998 + 492 WP_000919350.1 staphylokinase -
DXE29_RS14565 2826648..2826983 + 336 Protein_2696 SH3 domain-containing protein -
DXE29_RS14570 2827078..2827527 - 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
DXE29_RS14575 2828212..2828562 + 351 WP_000702263.1 complement inhibitor SCIN-A -
DXE29_RS14580 2828615..2828875 - 261 WP_001791826.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sak / chp / scn 2787718..2831145 43427


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T294127 WP_011447039.1 NZ_LT992463:2823907-2824083 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 175 bp

>AT294127 NZ_LT992463:c2824245-2824071 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References