Detailed information of TA system TA294118

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 558246..558825
• Replicon: chromosome
• Accession: NZ_LT992463
• Organism: Staphylococcus aureus isolate 2_LA_86

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: DXE29_RS02625
• Protein ID: WP_001025401.1
• Coordinates: 558246..558491 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	558460..558825 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE29_RS02580	554237..554851	+	615	WP_000191461.1	hypothetical protein	-
DXE29_RS02585	554848..554994	-	147	WP_001013104.1	hypothetical protein	-
DXE29_RS02590	555224..555808	-	585	WP_000825948.1	hypothetical protein	-
DXE29_RS02595	555826..556284	-	459	WP_000521395.1	hypothetical protein	-
DXE29_RS02600	556306..556632	-	327	WP_000455972.1	helix-turn-helix domain-containing protein	-
DXE29_RS02605	556795..557004	+	210	WP_001114715.1	helix-turn-helix transcriptional regulator	-
DXE29_RS02610	557043..557819	+	777	WP_031886646.1	Rha family transcriptional regulator	-
DXE29_RS02615	557848..557991	+	144	WP_000939498.1	hypothetical protein	-
DXE29_RS02620	557981..558190	-	210	WP_000642492.1	hypothetical protein	-
DXE29_RS02625	558246..558491	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
DXE29_RS02630	558460..558825	-	366	WP_001128433.1	hypothetical protein	Antitoxin
DXE29_RS02635	558880..559095	+	216	WP_001036302.1	hypothetical protein	-
DXE29_RS02640	559120..559383	+	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
DXE29_RS02645	559396..559557	+	162	WP_001285948.1	DUF1270 domain-containing protein	-
DXE29_RS02650	559636..559959	+	324	WP_000174994.1	hypothetical protein	-
DXE29_RS02655	559974..560336	+	363	WP_000985976.1	hypothetical protein	-
DXE29_RS02660	560333..561499	+	1167	WP_000762545.1	DUF2800 domain-containing protein	-
DXE29_RS02665	561525..562082	+	558	WP_031915349.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	geh	543678..598014	54336

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T294118 WP_001025401.1 NZ_LT992463:558246-558491 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT294118 NZ_LT992463:c558825-558460 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin