Detailed information of TA system TA294116

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2933335..2933687
• Replicon: chromosome
• Accession: NZ_LT992462
• Organism: Staphylococcus aureus isolate 5_3949

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: DXE65_RS15305
• Protein ID: WP_001025401.1
• Coordinates: 2933335..2933580 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2933549..2933687 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE65_RS15265	2929471..2930085	+	615	WP_000191466.1	hypothetical protein	-
DXE65_RS15270	2930082..2930228	-	147	WP_001013104.1	hypothetical protein	-
DXE65_RS15275	2930458..2931042	-	585	WP_031886768.1	hypothetical protein	-
DXE65_RS15280	2931099..2931728	-	630	WP_029549401.1	XRE family transcriptional regulator	-
DXE65_RS15285	2931882..2932109	+	228	WP_015978369.1	helix-turn-helix transcriptional regulator	-
DXE65_RS15290	2932132..2932908	+	777	WP_031838392.1	Rha family transcriptional regulator	-
DXE65_RS15295	2932937..2933080	+	144	WP_000939498.1	hypothetical protein	-
DXE65_RS15300	2933070..2933279	-	210	WP_000642492.1	hypothetical protein	-
DXE65_RS15305	2933335..2933580	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
-	2933549..2933687	-	139	-	-	Antitoxin
DXE65_RS15310	2933704..2933919	+	216	WP_001097552.1	hypothetical protein	-
DXE65_RS15315	2933944..2934207	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
DXE65_RS15320	2934220..2934381	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
DXE65_RS15325	2934460..2934783	+	324	WP_031914478.1	hypothetical protein	-
DXE65_RS15330	2934798..2935160	+	363	WP_031914479.1	hypothetical protein	-
DXE65_RS15335	2935157..2936323	+	1167	WP_031795549.1	DUF2800 domain-containing protein	-
DXE65_RS15340	2936349..2936906	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2928139..2959059	30920

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T294116 WP_001025401.1 NZ_LT992462:2933335-2933580 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 139 bp

>AT294116 NZ_LT992462:c2933687-2933549 [Staphylococcus aureus]
CGTGTATGCTAGTAACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACA
ATTTAAAAAGTATCATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin