Detailed information of TA system TA294111

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1960533..1960812
• Replicon: chromosome
• Accession: NZ_LT992462
• Organism: Staphylococcus aureus isolate 5_3949

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: DXE65_RS10500
• Protein ID: WP_001802298.1
• Coordinates: 1960708..1960812 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1960533..1960712 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE65_RS10480	1956734..1957399	-	666	WP_001024099.1	SDR family oxidoreductase	-
DXE65_RS10485	1957551..1957871	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
DXE65_RS10490	1957873..1958853	+	981	WP_000019735.1	CDF family zinc efflux transporter CzrB	-
DXE65_RS10495	1959119..1960210	+	1092	WP_000495673.1	hypothetical protein	-
-	1960533..1960712	+	180	-	-	Antitoxin
DXE65_RS10500	1960708..1960812	-	105	WP_001802298.1	hypothetical protein	Toxin
DXE65_RS15545	1961329..1961499	+	171	WP_001807897.1	hypothetical protein	-
DXE65_RS10515	1961492..1961650	+	159	WP_001792784.1	hypothetical protein	-
DXE65_RS10520	1962086..1962178	+	93	WP_000220902.1	hypothetical protein	-
DXE65_RS10525	1962308..1963165	-	858	WP_000370942.1	Cof-type HAD-IIB family hydrolase	-
DXE65_RS10530	1963233..1964015	-	783	WP_000908191.1	ABC transporter ATP-binding protein	-
DXE65_RS10535	1964305..1964913	-	609	WP_000101714.1	TIR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T294111 WP_001802298.1 NZ_LT992462:c1960812-1960708 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

Antitoxin

Nucleotide

• Length: 180 bp

>AT294111 NZ_LT992462:1960533-1960712 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin