294101

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprA2AS/-
Location 728280..728579 Replicon chromosome
Accession NZ_LT992462
Organism Staphylococcus aureus isolate 5_3949

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag DXE65_RS03610 Protein ID WP_011447039.1
Coordinates 728403..728579 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 728280..728335 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE65_RS03565 723610..723870 + 261 WP_001791826.1 hypothetical protein -
DXE65_RS03570 723923..724273 - 351 WP_000702263.1 complement inhibitor SCIN-A -
DXE65_RS03575 724959..725408 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
DXE65_RS03580 725503..725838 - 336 Protein_675 SH3 domain-containing protein -
DXE65_RS03590 726488..726979 - 492 WP_000919350.1 staphylokinase -
DXE65_RS03595 727170..727925 - 756 WP_000861038.1 CHAP domain-containing protein -
DXE65_RS03600 727937..728191 - 255 WP_000611512.1 phage holin -
DXE65_RS03605 728243..728350 + 108 WP_001791821.1 hypothetical protein -
- 728272..728411 + 140 NuclAT_0 - -
- 728272..728411 + 140 NuclAT_0 - -
- 728272..728411 + 140 NuclAT_0 - -
- 728272..728411 + 140 NuclAT_0 - -
- 728280..728335 + 56 - - Antitoxin
DXE65_RS03610 728403..728579 - 177 WP_011447039.1 putative holin-like toxin Toxin
DXE65_RS03615 728688..729461 - 774 WP_000750406.1 staphylococcal enterotoxin type A -
DXE65_RS03625 729882..730256 - 375 WP_000340977.1 hypothetical protein -
DXE65_RS03630 730312..730599 - 288 WP_001040259.1 hypothetical protein -
DXE65_RS03635 730646..730798 - 153 WP_001153681.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp / scn / chp / sak / sea 690310..795503 105193


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T294101 WP_011447039.1 NZ_LT992462:c728579-728403 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 56 bp

>AT294101 NZ_LT992462:728280-728335 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References