294086

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 213221..213520 Replicon chromosome
Accession NZ_LT992461
Organism Staphylococcus aureus isolate 8_LA_272

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag DXE60_RS01350 Protein ID WP_011447039.1
Coordinates 213344..213520 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 213221..213276 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE60_RS01290 208780..208959 + 180 WP_000669789.1 hypothetical protein -
DXE60_RS01300 209270..209530 + 261 WP_001791826.1 hypothetical protein -
DXE60_RS01305 209582..209932 - 351 WP_000702263.1 complement inhibitor SCIN-A -
DXE60_RS01310 210443..210778 - 336 Protein_213 SH3 domain-containing protein -
DXE60_RS01330 211429..211920 - 492 WP_031865878.1 staphylokinase -
DXE60_RS01335 212111..212866 - 756 WP_000861038.1 CHAP domain-containing protein -
DXE60_RS01340 212878..213132 - 255 WP_000611512.1 phage holin -
DXE60_RS01345 213184..213291 + 108 WP_001791821.1 hypothetical protein -
- 213213..213352 + 140 NuclAT_0 - -
- 213213..213352 + 140 NuclAT_0 - -
- 213213..213352 + 140 NuclAT_0 - -
- 213213..213352 + 140 NuclAT_0 - -
- 213221..213276 + 56 - - Antitoxin
DXE60_RS01350 213344..213520 - 177 WP_011447039.1 putative holin-like toxin Toxin
DXE60_RS01355 213670..213966 - 297 WP_000539688.1 DUF2951 domain-containing protein -
DXE60_RS01360 214024..214311 - 288 WP_001040261.1 hypothetical protein -
DXE60_RS01365 214358..214510 - 153 WP_001153681.1 hypothetical protein -
DXE60_RS01370 214500..218285 - 3786 WP_000582158.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / sak 209582..249657 40075


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T294086 WP_011447039.1 NZ_LT992461:c213520-213344 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 56 bp

>AT294086 NZ_LT992461:213221-213276 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References