Detailed information of TA system TA294085

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 213213..213520
• Replicon: chromosome
• Accession: NZ_LT992461
• Organism: Staphylococcus aureus isolate 8_LA_272

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: DXE60_RS01350
• Protein ID: WP_011447039.1
• Coordinates: 213344..213520 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	213213..213352 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE60_RS01290	208780..208959	+	180	WP_000669789.1	hypothetical protein	-
DXE60_RS01300	209270..209530	+	261	WP_001791826.1	hypothetical protein	-
DXE60_RS01305	209582..209932	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
DXE60_RS01310	210443..210778	-	336	Protein_213	SH3 domain-containing protein	-
DXE60_RS01330	211429..211920	-	492	WP_031865878.1	staphylokinase	-
DXE60_RS01335	212111..212866	-	756	WP_000861038.1	CHAP domain-containing protein	-
DXE60_RS01340	212878..213132	-	255	WP_000611512.1	phage holin	-
DXE60_RS01345	213184..213291	+	108	WP_001791821.1	hypothetical protein	-
-	213213..213352	+	140	NuclAT_0	-	Antitoxin
-	213213..213352	+	140	NuclAT_0	-	Antitoxin
-	213213..213352	+	140	NuclAT_0	-	Antitoxin
-	213213..213352	+	140	NuclAT_0	-	Antitoxin
DXE60_RS01350	213344..213520	-	177	WP_011447039.1	putative holin-like toxin	Toxin
DXE60_RS01355	213670..213966	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
DXE60_RS01360	214024..214311	-	288	WP_001040261.1	hypothetical protein	-
DXE60_RS01365	214358..214510	-	153	WP_001153681.1	hypothetical protein	-
DXE60_RS01370	214500..218285	-	3786	WP_000582158.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak	209582..249657	40075

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T294085 WP_011447039.1 NZ_LT992461:c213520-213344 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT294085 NZ_LT992461:213213-213352 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin