Detailed information of TA system TA294075

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1569809..1570088
• Replicon: chromosome
• Accession: NZ_LT992460
• Organism: Staphylococcus aureus isolate 9_LA_281

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: DXE39_RS08115
• Protein ID: WP_001802298.1
• Coordinates: 1569809..1569913 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1569909..1570088 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE39_RS08080	1565708..1566316	+	609	WP_000101714.1	TIR domain-containing protein	-
DXE39_RS08085	1566606..1567388	+	783	WP_000908191.1	ABC transporter ATP-binding protein	-
DXE39_RS08090	1567456..1568313	+	858	WP_000370942.1	Cof-type HAD-IIB family hydrolase	-
DXE39_RS08095	1568443..1568535	-	93	WP_000220902.1	hypothetical protein	-
DXE39_RS08100	1568971..1569129	-	159	WP_001792784.1	hypothetical protein	-
DXE39_RS08115	1569809..1569913	+	105	WP_001802298.1	hypothetical protein	Toxin
-	1569909..1570088	-	180	-	-	Antitoxin
DXE39_RS08120	1570411..1571502	-	1092	WP_000495673.1	hypothetical protein	-
DXE39_RS08125	1571768..1572748	-	981	WP_000019735.1	CDF family zinc efflux transporter CzrB	-
DXE39_RS08130	1572750..1573070	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
DXE39_RS08135	1573222..1573887	+	666	WP_001024099.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T294075 WP_001802298.1 NZ_LT992460:1569809-1569913 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

Antitoxin

Nucleotide

• Length: 180 bp

>AT294075 NZ_LT992460:c1570088-1569909 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin