Detailed information of TA system TA294071

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 597706..598285
• Replicon: chromosome
• Accession: NZ_LT992460
• Organism: Staphylococcus aureus isolate 9_LA_281

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: DXE39_RS03290
• Protein ID: WP_001025401.1
• Coordinates: 598040..598285 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	597706..598071 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE39_RS03250	594451..595005	-	555	WP_000647288.1	DUF2815 family protein	-
DXE39_RS03255	595032..596198	-	1167	WP_031775793.1	DUF2800 domain-containing protein	-
DXE39_RS03260	596195..596557	-	363	WP_031775792.1	hypothetical protein	-
DXE39_RS03265	596572..596895	-	324	WP_000175000.1	hypothetical protein	-
DXE39_RS03270	596974..597135	-	162	WP_001285962.1	DUF1270 domain-containing protein	-
DXE39_RS03275	597148..597411	-	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
DXE39_RS03280	597436..597651	-	216	WP_001036302.1	hypothetical protein	-
DXE39_RS03285	597706..598071	+	366	WP_001128433.1	hypothetical protein	Antitoxin
DXE39_RS03290	598040..598285	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
DXE39_RS03295	598341..598550	+	210	WP_000642492.1	hypothetical protein	-
DXE39_RS03300	598540..598683	-	144	WP_000939498.1	hypothetical protein	-
DXE39_RS03305	598712..599488	-	777	WP_031886646.1	Rha family transcriptional regulator	-
DXE39_RS03310	599511..599738	-	228	WP_015978369.1	helix-turn-helix transcriptional regulator	-
DXE39_RS03315	599892..600521	+	630	WP_029549401.1	XRE family transcriptional regulator	-
DXE39_RS03320	600578..601162	+	585	WP_114647903.1	hypothetical protein	-
DXE39_RS03325	601392..601538	+	147	WP_001013104.1	hypothetical protein	-
DXE39_RS03330	601535..602149	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	558762..603480	44718

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T294071 WP_001025401.1 NZ_LT992460:c598285-598040 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT294071 NZ_LT992460:597706-598071 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin