294068

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 186681..186980 Replicon chromosome
Accession NZ_LT992460
Organism Staphylococcus aureus isolate 9_LA_281

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag DXE39_RS00995 Protein ID WP_011447039.1
Coordinates 186804..186980 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 186681..186736 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE39_RS00950 182011..182271 + 261 WP_001791826.1 hypothetical protein -
DXE39_RS00955 182324..182674 - 351 WP_000702263.1 complement inhibitor SCIN-A -
DXE39_RS00960 183360..183809 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
DXE39_RS00965 183904..184239 - 336 Protein_181 SH3 domain-containing protein -
DXE39_RS00975 184889..185380 - 492 WP_000919350.1 staphylokinase -
DXE39_RS00980 185571..186326 - 756 WP_000861038.1 CHAP domain-containing protein -
DXE39_RS00985 186338..186592 - 255 WP_000611512.1 phage holin -
DXE39_RS00990 186644..186751 + 108 WP_001791821.1 hypothetical protein -
- 186673..186812 + 140 NuclAT_0 - -
- 186673..186812 + 140 NuclAT_0 - -
- 186673..186812 + 140 NuclAT_0 - -
- 186673..186812 + 140 NuclAT_0 - -
- 186681..186736 + 56 - - Antitoxin
DXE39_RS00995 186804..186980 - 177 WP_011447039.1 putative holin-like toxin Toxin
DXE39_RS01000 187089..187862 - 774 WP_000750406.1 staphylococcal enterotoxin type A -
DXE39_RS01010 188283..188657 - 375 WP_000340977.1 hypothetical protein -
DXE39_RS01015 188713..189000 - 288 WP_001040259.1 hypothetical protein -
DXE39_RS01020 189047..189199 - 153 WP_001153681.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - scn / chp / sak / sea 139209..260435 121226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T294068 WP_011447039.1 NZ_LT992460:c186980-186804 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 56 bp

>AT294068 NZ_LT992460:186681-186736 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References