Detailed information of TA system TA294067

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 186673..186980
• Replicon: chromosome
• Accession: NZ_LT992460
• Organism: Staphylococcus aureus isolate 9_LA_281

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: DXE39_RS00995
• Protein ID: WP_011447039.1
• Coordinates: 186804..186980 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	186673..186812 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE39_RS00950	182011..182271	+	261	WP_001791826.1	hypothetical protein	-
DXE39_RS00955	182324..182674	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
DXE39_RS00960	183360..183809	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
DXE39_RS00965	183904..184239	-	336	Protein_181	SH3 domain-containing protein	-
DXE39_RS00975	184889..185380	-	492	WP_000919350.1	staphylokinase	-
DXE39_RS00980	185571..186326	-	756	WP_000861038.1	CHAP domain-containing protein	-
DXE39_RS00985	186338..186592	-	255	WP_000611512.1	phage holin	-
DXE39_RS00990	186644..186751	+	108	WP_001791821.1	hypothetical protein	-
-	186673..186812	+	140	NuclAT_0	-	Antitoxin
-	186673..186812	+	140	NuclAT_0	-	Antitoxin
-	186673..186812	+	140	NuclAT_0	-	Antitoxin
-	186673..186812	+	140	NuclAT_0	-	Antitoxin
DXE39_RS00995	186804..186980	-	177	WP_011447039.1	putative holin-like toxin	Toxin
DXE39_RS01000	187089..187862	-	774	WP_000750406.1	staphylococcal enterotoxin type A	-
DXE39_RS01010	188283..188657	-	375	WP_000340977.1	hypothetical protein	-
DXE39_RS01015	188713..189000	-	288	WP_001040259.1	hypothetical protein	-
DXE39_RS01020	189047..189199	-	153	WP_001153681.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	scn / chp / sak / sea	139209..260435	121226

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T294067 WP_011447039.1 NZ_LT992460:c186980-186804 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT294067 NZ_LT992460:186673-186812 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin