Detailed information of TA system TA294063

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2402287..2402484
• Replicon: chromosome
• Accession: NZ_LT992458
• Organism: Staphylococcus aureus isolate 7_4623

Toxin (Protein)

• Gene name: SprG2
• Uniprot ID: -
• Locus tag: DXE63_RS12440
• Protein ID: WP_000623369.1
• Coordinates: 2402377..2402484 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2402287..2402324 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE63_RS12405	2397388..2397744	+	357	WP_000766009.1	DoxX family protein	-
DXE63_RS12410	2397833..2398021	-	189	WP_157958947.1	poly(glycerol-phosphate) alpha-glucosyltransferase	-
DXE63_RS12415	2398111..2398401	+	291	WP_001796515.1	hypothetical protein	-
DXE63_RS12420	2398489..2399130	-	642	WP_000571192.1	ABC transporter ATP-binding protein	-
DXE63_RS12425	2399127..2399447	-	321	WP_000668623.1	YxeA family protein	-
DXE63_RS12430	2399450..2401414	-	1965	WP_000870811.1	bacteriocin-associated integral membrane family protein	-
DXE63_RS12435	2401458..2401742	-	285	WP_000790905.1	lactococcin 972 family bacteriocin	-
-	2402287..2402324	+	38	-	-	Antitoxin
DXE63_RS12440	2402377..2402484	-	108	WP_000623369.1	putative holin-like toxin	Toxin
DXE63_RS12445	2402754..2403356	-	603	WP_001033867.1	CPBP family intramembrane metalloprotease	-
DXE63_RS12450	2403371..2403547	-	177	WP_000214898.1	YkvS family protein	-
DXE63_RS12455	2403746..2404732	+	987	WP_000668814.1	lipoate--protein ligase	-
DXE63_RS12460	2404813..2405031	-	219	WP_000876826.1	IDEAL domain-containing protein	-
DXE63_RS12465	2405241..2405810	+	570	WP_000287265.1	competence protein ComK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3801.69 Da
• Isoelectric Point: 10.8004

>T294063 WP_000623369.1 NZ_LT992458:c2402484-2402377 [Staphylococcus aureus]
VISIANALHLMLSFGMFIVTFIGVVVAIINLNNKK

Nucleotide

• Length: 108 bp

Antitoxin

Nucleotide

• Length: 38 bp

>AT294063 NZ_LT992458:2402287-2402324 [Staphylococcus aureus]
AACATGTCGCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Antitoxin