Detailed information of TA system TA294060

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprA2AS/-
• Location: 1405243..1405550
• Replicon: chromosome
• Accession: NZ_LT992458
• Organism: Staphylococcus aureus isolate 7_4623

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: DXE63_RS07300
• Protein ID: WP_072357969.1
• Coordinates: 1405243..1405419 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1405409..1405550 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE63_RS07280	1400476..1404261	+	3786	WP_114621343.1	hypothetical protein	-
DXE63_RS07285	1404251..1404403	+	153	WP_001153681.1	hypothetical protein	-
DXE63_RS07290	1404450..1404737	+	288	WP_052997141.1	hypothetical protein	-
DXE63_RS07295	1404795..1405091	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
DXE63_RS07300	1405243..1405419	+	177	WP_072357969.1	putative holin-like toxin	Toxin
-	1405409..1405550	-	142	-	-	Antitoxin
DXE63_RS07310	1405631..1405885	+	255	WP_000611512.1	phage holin	-
DXE63_RS07315	1405897..1406652	+	756	WP_000861038.1	CHAP domain-containing protein	-
DXE63_RS07320	1406843..1407334	+	492	WP_052997142.1	staphylokinase	-
DXE63_RS07340	1407985..1408319	+	335	Protein_1364	SH3 domain-containing protein	-
DXE63_RS07345	1408412..1408861	-	450	WP_000727643.1	chemotaxis-inhibiting protein CHIPS	-
DXE63_RS07350	1409544..1409894	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
DXE63_RS07355	1409947..1410207	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	1357274..1409894	52620

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T294060 WP_072357969.1 NZ_LT992458:1405243-1405419 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 142 bp

>AT294060 NZ_LT992458:c1405550-1405409 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin