Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 1218251..1218514 Replicon chromosome
Accession NZ_LT992458
Organism Staphylococcus aureus isolate 7_4623

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag DXE63_RS06215 Protein ID WP_001802298.1
Coordinates 1218251..1218355 (+) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 1218350..1218514 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE63_RS06180 1214150..1214758 + 609 WP_000101714.1 TIR domain-containing protein -
DXE63_RS06185 1215048..1215830 + 783 WP_000908191.1 ABC transporter ATP-binding protein -
DXE63_RS06190 1215898..1216755 + 858 WP_000370942.1 Cof-type HAD-IIB family hydrolase -
DXE63_RS06195 1216885..1216977 - 93 WP_000220902.1 hypothetical protein -
DXE63_RS06200 1217413..1217571 - 159 WP_001792784.1 hypothetical protein -
DXE63_RS06215 1218251..1218355 + 105 WP_001802298.1 hypothetical protein Toxin
- 1218350..1218514 - 165 - - Antitoxin
DXE63_RS06220 1218853..1219944 - 1092 WP_000495673.1 hypothetical protein -
DXE63_RS06225 1220210..1221190 - 981 WP_000019735.1 CDF family zinc efflux transporter CzrB -
DXE63_RS06230 1221192..1221512 - 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
DXE63_RS06235 1221664..1222329 + 666 WP_001024099.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T294053 WP_001802298.1 NZ_LT992458:1218251-1218355 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

Antitoxin


Download         Length: 165 bp

>AT294053 NZ_LT992458:c1218514-1218350 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References