Detailed information of TA system TA294049

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 239353..239932
• Replicon: chromosome
• Accession: NZ_LT992458
• Organism: Staphylococcus aureus isolate 7_4623

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: DXE63_RS01365
• Protein ID: WP_001025401.1
• Coordinates: 239687..239932 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	239353..239718 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE63_RS01325	236096..236653	-	558	WP_000645042.1	DUF2815 family protein	-
DXE63_RS01330	236679..237845	-	1167	WP_000762547.1	DUF2800 domain-containing protein	-
DXE63_RS01335	237842..238204	-	363	WP_031775157.1	hypothetical protein	-
DXE63_RS01340	238219..238542	-	324	WP_000174994.1	hypothetical protein	-
DXE63_RS01345	238621..238782	-	162	WP_001285963.1	DUF1270 family protein	-
DXE63_RS01350	238795..239058	-	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
DXE63_RS01355	239083..239298	-	216	WP_001036302.1	hypothetical protein	-
DXE63_RS01360	239353..239718	+	366	WP_001128433.1	hypothetical protein	Antitoxin
DXE63_RS01365	239687..239932	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
DXE63_RS01370	239948..240196	-	249	WP_000272860.1	helix-turn-helix domain-containing protein	-
DXE63_RS01375	240360..240683	+	324	WP_001260485.1	helix-turn-helix domain-containing protein	-
DXE63_RS01380	240696..241157	+	462	WP_031838007.1	toxin	-
DXE63_RS01385	241175..241609	+	435	WP_000755718.1	hypothetical protein	-
DXE63_RS01390	241638..242033	+	396	WP_000449655.1	hypothetical protein	-
DXE63_RS01395	242123..242269	+	147	WP_074370993.1	hypothetical protein	-
DXE63_RS01400	242266..242880	-	615	WP_000191466.1	hypothetical protein	-
DXE63_RS01405	243006..244211	+	1206	WP_000264745.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	200170..244211	44041

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T294049 WP_001025401.1 NZ_LT992458:c239932-239687 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT294049 NZ_LT992458:239353-239718 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin