Detailed information of TA system TA294044

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2099676..2099983
• Replicon: chromosome
• Accession: NZ_LT992456
• Organism: Staphylococcus aureus isolate 1_1439

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: DXE58_RS10735
• Protein ID: WP_011447039.1
• Coordinates: 2099676..2099852 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2099844..2099983 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE58_RS10715	2094911..2098696	+	3786	WP_000582165.1	hypothetical protein	-
DXE58_RS10720	2098686..2098838	+	153	WP_001153681.1	hypothetical protein	-
DXE58_RS10725	2098885..2099172	+	288	WP_001040261.1	hypothetical protein	-
DXE58_RS10730	2099230..2099526	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
DXE58_RS10735	2099676..2099852	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	2099844..2099983	-	140	NuclAT_0	-	Antitoxin
-	2099844..2099983	-	140	NuclAT_0	-	Antitoxin
-	2099844..2099983	-	140	NuclAT_0	-	Antitoxin
-	2099844..2099983	-	140	NuclAT_0	-	Antitoxin
DXE58_RS10740	2099905..2100012	-	108	WP_001791821.1	hypothetical protein	-
DXE58_RS10745	2100064..2100318	+	255	WP_000611512.1	phage holin	-
DXE58_RS10750	2100330..2101085	+	756	WP_064131634.1	CHAP domain-containing protein	-
DXE58_RS10755	2101276..2101767	+	492	WP_000919350.1	staphylokinase	-
DXE58_RS10765	2102417..2102752	+	336	Protein_2004	SH3 domain-containing protein	-
DXE58_RS10770	2102847..2103297	-	451	Protein_2005	chemotaxis-inhibiting protein CHIPS	-
DXE58_RS10775	2103982..2104332	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
DXE58_RS10780	2104385..2104645	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	2052708..2104332	51624

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T294044 WP_011447039.1 NZ_LT992456:2099676-2099852 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT294044 NZ_LT992456:c2099983-2099844 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin