Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 2099676..2100014 Replicon chromosome
Accession NZ_LT992456
Organism Staphylococcus aureus isolate 1_1439

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag DXE58_RS10735 Protein ID WP_011447039.1
Coordinates 2099676..2099852 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2099840..2100014 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE58_RS10715 2094911..2098696 + 3786 WP_000582165.1 hypothetical protein -
DXE58_RS10720 2098686..2098838 + 153 WP_001153681.1 hypothetical protein -
DXE58_RS10725 2098885..2099172 + 288 WP_001040261.1 hypothetical protein -
DXE58_RS10730 2099230..2099526 + 297 WP_000539688.1 DUF2951 domain-containing protein -
DXE58_RS10735 2099676..2099852 + 177 WP_011447039.1 putative holin-like toxin Toxin
- 2099840..2100014 - 175 - - Antitoxin
DXE58_RS10745 2100064..2100318 + 255 WP_000611512.1 phage holin -
DXE58_RS10750 2100330..2101085 + 756 WP_064131634.1 CHAP domain-containing protein -
DXE58_RS10755 2101276..2101767 + 492 WP_000919350.1 staphylokinase -
DXE58_RS10765 2102417..2102752 + 336 Protein_2004 SH3 domain-containing protein -
DXE58_RS10770 2102847..2103297 - 451 Protein_2005 chemotaxis-inhibiting protein CHIPS -
DXE58_RS10775 2103982..2104332 + 351 WP_000702263.1 complement inhibitor SCIN-A -
DXE58_RS10780 2104385..2104645 - 261 WP_001791826.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / hlb / sak / chp / scn 2052708..2104332 51624


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T294042 WP_011447039.1 NZ_LT992456:2099676-2099852 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 175 bp

>AT294042 NZ_LT992456:c2100014-2099840 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References