Detailed information of TA system TA294037

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1927112..1927375
• Replicon: chromosome
• Accession: NZ_LT992456
• Organism: Staphylococcus aureus isolate 1_1439

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: DXE58_RS09740
• Protein ID: WP_001802298.1
• Coordinates: 1927112..1927216 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	1927211..1927375 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE58_RS09705	1923011..1923619	+	609	WP_000101714.1	TIR domain-containing protein	-
DXE58_RS09710	1923909..1924691	+	783	WP_000908191.1	ABC transporter ATP-binding protein	-
DXE58_RS09715	1924759..1925616	+	858	WP_000370942.1	Cof-type HAD-IIB family hydrolase	-
DXE58_RS09720	1925746..1925838	-	93	WP_000220902.1	hypothetical protein	-
DXE58_RS09725	1926274..1926432	-	159	WP_001792784.1	hypothetical protein	-
DXE58_RS09740	1927112..1927216	+	105	WP_001802298.1	hypothetical protein	Toxin
-	1927211..1927375	-	165	-	-	Antitoxin
DXE58_RS09745	1927648..1928739	-	1092	WP_000495673.1	hypothetical protein	-
DXE58_RS09750	1929005..1929985	-	981	WP_000019735.1	CDF family zinc efflux transporter CzrB	-
DXE58_RS09755	1929987..1930307	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
DXE58_RS09760	1930459..1931124	+	666	WP_001024099.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T294037 WP_001802298.1 NZ_LT992456:1927112-1927216 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

Antitoxin

Nucleotide

• Length: 165 bp

>AT294037 NZ_LT992456:c1927375-1927211 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin