Detailed information of TA system TA029403

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-couple_hipB
• Location: 611158..611806
• Replicon: chromosome
• Accession: NC_021175
• Organism: Streptococcus oligofermentans AS 1.3089

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A512AB01
• Locus tag: I872_RS02950
• Protein ID: WP_015604673.1
• Coordinates: 611158..611523 (+)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A512AAX1
• Locus tag: I872_RS02955
• Protein ID: WP_015604674.1
• Coordinates: 611513..611806 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I872_RS02925	606872..607696	+	825	WP_015604667.1	ATP-binding protein	-
I872_RS02930	608002..608448	+	447	WP_015604668.1	hypothetical protein	-
I872_RS12000	608763..608939	+	177	WP_015604669.1	hypothetical protein	-
I872_RS02935	609018..609650	+	633	WP_015604670.1	hypothetical protein	-
I872_RS02940	609659..610141	+	483	WP_015604671.1	hypothetical protein	-
I872_RS02945	610122..610532	+	411	WP_015604672.1	hypothetical protein	-
I872_RS02950	611158..611523	+	366	WP_015604673.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I872_RS02955	611513..611806	+	294	WP_015604674.1	helix-turn-helix transcriptional regulator	Antitoxin
I872_RS02960	612074..612649	+	576	WP_015604675.1	hypothetical protein	-
I872_RS02965	612867..613052	-	186	WP_015604676.1	hypothetical protein	-
I872_RS02970	613126..614136	-	1011	WP_015604677.1	lactonase family protein	-
I872_RS02975	614376..614642	+	267	WP_015604678.1	hypothetical protein	-
I872_RS02980	614671..615936	+	1266	WP_015604679.1	efflux RND transporter periplasmic adaptor subunit	-
I872_RS02985	615923..616597	+	675	WP_015604680.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	602331..616597	14266

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (35-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-88)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 14448.59 Da
• Isoelectric Point: 9.5773

>T29403 WP_015604673.1 NC_021175:611158-611523 [Streptococcus cristatus AS 1.3089]
VHNIYFYKDKNGNEPVLDYMRELASKKGKDSRIKLNKINDYIELLSQHGTRAGEPYIKHLDAEIWELRPLRDRVLFVAWI
DGSFVLLHHFMKKTQKTPKREIEQAKRELEDLKERGLDNEK

Nucleotide

• Length: 366 bp

>T29403 NC_021175:611158-611523 [Streptococcus cristatus AS 1.3089]
GTGCATAATATCTATTTTTACAAGGATAAGAACGGTAATGAGCCTGTTTTAGATTATATGCGAGAGCTTGCCAGTAAAAA
GGGAAAAGATAGTAGAATTAAACTCAATAAAATCAATGATTATATTGAGTTGTTAAGCCAGCATGGAACACGCGCAGGTG
AGCCATATATTAAGCATTTAGATGCTGAAATTTGGGAACTTAGACCACTAAGGGATAGGGTTTTATTTGTTGCTTGGATT
GATGGCAGTTTCGTTTTATTGCATCATTTTATGAAAAAGACACAGAAGACTCCAAAGAGAGAAATTGAACAAGCCAAGCG
TGAATTAGAAGATTTAAAAGAAAGAGGGCTAGATAATGAAAAATAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10678.33 Da
• Isoelectric Point: 5.1991

>AT29403 WP_015604674.1 NC_021175:611513-611806 [Streptococcus cristatus AS 1.3089]
MKNSAIGSNWKDVRAELFSKEEILESDMRVAIMSELIEARNEKGISQKKLEELSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEHEQA

Nucleotide

• Length: 294 bp

>AT29403 NC_021175:611513-611806 [Streptococcus cristatus AS 1.3089]
ATGAAAAATAGTGCGATCGGCAGCAATTGGAAAGATGTTAGAGCTGAGCTTTTTAGCAAAGAGGAGATTTTAGAAAGTGA
TATGCGCGTGGCTATCATGAGCGAGCTTATCGAGGCCAGAAATGAGAAGGGAATAAGCCAAAAGAAATTGGAGGAATTAA
GTGGTGTAAGTCAGCCTGTCATTGCTAGAATGGAAACAGGTAAGACAAGCCCGCAACTGGACACGGTGCTAAAAGTATTA
GCAAGTCTGGGAAAAACTTTAGCAGTGGTACCTTTAGAACATGAACAGGCATAG

Structures

Toxin

• AlphaFold DB: A0A512AB01

Antitoxin

• AlphaFold DB: A0A512AAX1